Surgeries in patients treated prophylactically with emicizumab (including surgical procedures a high risk of postoperative bleeding) are not associated higher risks or technical difficulties compared operations receiving standard replacement therapy. On the contrary, presence blood and its maintenance permanent basic hemostasis allow for reduction doses infusion time bypassing agents. Patients ...

Translating ribosomes bypass a 50 nucleotide coding gap in bacteriophage T4 gene 60 mRNA between codons 46 and 47 in order to synthesize the full-length protein. Bypassing of the coding gap requires peptidyl-tRNA2Gly detachment from a GGA codon (codon 46) followed by re-pairing at a matching GGA codon just before codon 47. Using negative selection, based on the sacB gene from Bacillus subtilis,...

Translational bypassing is a unique phenomenon of bacteriophage T4 gene 60 mRNA wherein the bacterial ribosome produces a single polypeptide chain from a discontinuous open reading frame (ORF). Upon reaching the 50-nucleotide untranslated region, or coding gap, the ribosome either dissociates or bypasses the interruption to continue translating the remainder of the ORF, generating a subunit of ...

Ribosomes translating bacteriophage T4 gene 60 mRNA bypass 50 noncoding nucleotides from a takeoff site at codon 46 to a landing site just upstream of codon 47. A key signal for efficient bypassing is contained within the nascent peptide synthesized prior to takeoff. Here we show that this signal is insensitive to the addition of coding information at its N terminus. In addition, analysis of am...

Large scale agent-based simulations typically face a trade-off between the level of detail in the representation of each agent and the scalability seen as the number of agents that can be simulated with the computing resources available. In this paper, we aim at bypassing this trade-off by considering that the level of detail is itself a parameter that can be adapted automatically and dynamical...

We prove that quasiconvex functions always admit descent trajectories bypassing all non-minimizing critical points.

The blood-brain barrier is a substantial obstacle for delivering anticancer agents to brain tumors, and new strategies for bypassing it are greatly needed for brain-tumor therapy. Intranasal delivery provides a practical, noninvasive method for delivering therapeutic agents to the brain and could provide an alternative to intravenous injection and convection-enhanced delivery. We treated rats b...

We present a supervised approach for learning policies in a highly complex game from small amounts of human data consisting of state–action pairs. Our Neural Network architecture can adapt to the varying size of the set of legal actions, thus bypassing the need to hardcode the actions in the output layer or iterate over them. This makes the training more data efficient. We use synthetic data cr...

Although recent innovations in transient plant systems have enabled gram quantities of proteins in 1-2 weeks, very few have been translated into applications due to technical challenges and high downstream processing costs. Here we report high-level production, using a Nicotiana benthamiana/p19 system, of an engineered recombinant human acetylcholinesterase (rAChE) that is highly stable in a mi...