We present an interactive contrast enhancement technique for the global histogram modification of images. Through direct manipulation, the user adjusts contrast by clicking on the image. Contrast around different key tones can be adjusted simultaneously and independently without altering their luminance. Histogram warping by monotonic splines performs the gray level mapping. User interfaces for...

Intramyocardial dissecting haematoma is a rare form of cardiac rupture that can occur as a complication following acute myocardial infarction or during the remodelling process. It is usually caused by a haemorrhagic dissection among the spiral myocardial fibres and needs urgent surgical treatment. Here we report the case of a 67-year-old man with indications of a previous infarction, in whom a ...

Copyright © 2006 Massachusetts Medical Society. A 71-year-old man with type 2 diabetes and hypertension is referred for coronary angiography. His medications include metformin and a thiazide. Before the angiogram, his serum creatinine level is 1.8 mg per deciliter (160 μmol per liter), yielding an estimated glomerular filtration rate of 40 ml per minute per 1.73 m2 of body-surface area. What ca...

Electron microscopy laboratory, School of Physics, and Center for Nanochemistry, Peking University, Beijing 100871, China Collaborative Innovation Center of Quantum Matter, Beijing 100871, China Center for Nanochemistry, Peking University, Beijing 100871, China Institute of Engineering Innovation, The University of Tokyo, Tokyo 113–8656, Japan Nanostructures Research Laboratory, Japan Fine Cera...

We present an automated algorithm for global contrast enhancement of images with multimodal histograms. To locate modes and valleys, histogram analysis is performed by kernel density estimation, a robust nonparametric statistical method. Histogram warping by monotonic splines pushes the modes apart, spreading them out more evenly across the dynamic range. This technique can assist in the contra...

Copyright © 2006 Massachusetts Medical Society. A 71-year-old man with type 2 diabetes and hypertension is referred for coronary angiography. His medications include metformin and a thiazide. Before the angiogram, his serum creatinine level is 1.8 mg per deciliter (160 μmol per liter), yielding an estimated glomerular filtration rate of 40 ml per minute per 1.73 m2 of body-surface area. What ca...

Several MRI contrast agents (CAs) are used in medical diagnosis that gadolinium (Gd3+) is the most widely used as contrast agents. Unfortunately, its toxicity is due to its inefficiency. In this review, we discuss about the ability of SPIONs in MRI and application in Multiple Sclerosis diagnosis. Superparamagnetic iron oxide nanoparticles (SPIONs) such as magnetite nanoparticles are used as goo...