The uptake of simian virus 40 (SV40) virions to the nucleus, the site of viral replication, proceeds via engulfment at the cytoplasmic membrane and transport in monopinocytotic vesicles through the cytoplasm to the nuclear membrane. In the case of Semliki Forest virus and poliovirus which undergo primary endocytosis in a similar manner, neutralization of the acid pH in these vesicles abolishes ...

Recently, the antiviral activity of kanamycin derivatives against influenza and herpes simplex virus has been reported1~3). The mechanism of antiviral action of these agents is not well understood. In this report, the mechanism of antiviral effect of 1-N-eicosanoyl-3"-N-(trifluoroacetyl)kanamycin (ETK), one of these agents, was studied. We have tried to test the effect of ETK on simian virus 40...