Plasma free fatty acid (FFA) kinetics in humans are often measured with only one tracer. In study 1, healthy volunteers received infusions of [U-¹³C]linoleate, [U-¹³C]oleate, and [U-¹³C]palmitate during continuous feeding with liquid meals low (n = 12) and high (n = 5) in palmitate and containing three labeled fatty acids to measure FFA appearance and fractional spillover of lipoprotein lipase-...

Rats maintained on low-fat (LF) or high-fat (HF) diets were fitted with gastric cannulas and duodenal catheters. Intraperitoneal injection of 0.250-2.0 microg/kg cholecystokinin (CCK) significantly inhibited gastric emptying of a 5-ml NaCl load in LF rats by 26.2-55. 1% compared with emptying after vehicle injection. By contrast, CCK-induced inhibition of gastric emptying was significantly less...

Little is known about the fate of the lipolytic products produced by the action of lipoprotein lipase (LPL) on circulating triglyceride-rich lipoproteins in humans. We studied eight lean, healthy male subjects after an overnight fast. Subjects received infusions of lipid emulsions containing triolein labeled with (3)H on both the glycerol backbone and the fatty acid portion of the molecule; (14...

Cellular responses to environmental stimuli are mediated by the co-ordinated activity of multiple control mechanisms, which result in the dynamics of cell function. Communication between different levels of regulation is central for this adaptability. The present study focuses on the interplay between transcriptional regulators and chromatin modifiers to co-operatively regulate transcription in...

We tested the hypothesis that excessive portal venous supply of long-chain fatty acids to the liver contributes to the development of insulin resistance via activation of the hypothalamus-pituitary-adrenal axis (HPA axis) and sympathetic system. Rats received an intraportal infusion of the long-chain fatty acid oleate (150 nmol/min, 24 h), the medium-chain fatty acid caprylate, or the solvent. ...

The uptake of propionate by the isolated perfused rat liver is not influenced by oleate or glucagon. However, glucagon does stimulate glucose production in the presence of 10 flwl propionate and increases the incorporation of isotope from [14C]propionate into glucose. These observations have been interpreted to indicate a sparing of the metabolism of propionate in the citric acid cycle by endog...

Silica chloride converted benzyl or tert-butyl esters to the corresponding acid chlorides and alkyl chlorides. It also converted benzyl or tert-butyl phenyl ethers to the corresponding allcyl chlorides and phenol

The uptake of propionate by the isolated perfused rat liver is not influenced by oleate or glucagon. However, glucagon does stimulate glucose production in the presence of 10 flwl propionate and increases the incorporation of isotope from [14C]propionate into glucose. These observations have been interpreted to indicate a sparing of the metabolism of propionate in the citric acid cycle by endog...

Anionic surfactants based on fatty acids are usually used to modify the particle surface properties of CaCO 3 with the aim to enhance its dispersion and compatibility with polymer matrices. In this study sodium oleate was used for the preparation of ultrahydrophobic CaCO 3 nanoparticles using a wet carbonation route. The effect of sodium oleate on the characteristics, particle size, morphology,...

(1) The levels of oleate and linoleate in the serum have been measured in 14 patients with multiple sclerosis (MS) and in 14 healthy subjects before, during and after a five day period when the normal diet was supplemented with linoleate. (2) In confirmation of earlier work the mean percentage of linoleate in the serum lipids of the MS patients was significantly lower (P < 0·01) than in the con...