نتایج جستجو برای: buspirone
تعداد نتایج: 563 فیلتر نتایج به سال:
s | 3 proline/alanine–rich kinase (pSPAK) and oxidative stress response kinase-1 (pOSR1), a master regulator of KCC2 and NKCC1 activity. The perisomatic expression of pSPAK/pOSR1 altered correspondingly to that of KCC2 and NKCC1. Finally, we administered diazepam, a GABAA-Receptor agonist, to RS-OVX mice with vehicle, alfaE2 and G1 to confirm the normalization of behavior, KCC2, NKCC1 and GPR30...
In an attempt to design novel 5-HT(1A) agonists/partial agonists, based on an arylpiperazine nucleus, a series of N-{4-[4-(aryl)piperazine-1-yl]-phenyl}-amine derivatives were synthesized and biologically tested. The anxiolytic effect of the compounds was investigated employing the Elevated plus Maze (EPM) task. On the basis of in vivo functional test, compound 1c (3mg/kg) and 4c (3mg/kg) induc...
1 Abbreviations used: HLM, human liver microsomes; HO-1-PP, 5-hydroxy-1-(2-pyrimidinyl)-piperazine; LC/MS, liquid chromatography/mass spectrometry; NADPH, β-nicotinamide adenine dinucleotide phosphate sodium (reduced form); 1-PP, 1-(2-pyrimidinyl)-piperazine ABSTRACT 1-(2-Pyrimidinyl)-piperazine (1-PP) is an active metabolite of several psychoactive drugs including buspirone. 1-PP is also the m...
Binding of [3H]serotonin (5-HT) to membranes prepared from Arctic charr brain homogenates was most consistent with a one-site model for [3H]5-HT binding, with KD and Bmax values of 5.7±0.3 nmol l−1 and 60.7±7.3 fmol mg−1 protein, respectively. Similarly, 5-HT displacement of [3H]5-HT was best explained by a monophasic model with an apparent Ki of 4.3±0.7 nmol l−1. The ability of a number of syn...
BACKGROUND We hypothesized that a substantial proportion of the subjectively experienced variance in pain in fibromyalgia patients would be explained by psychological factors alone, but that a combined model, including neuroendocrine and autonomic factors, would give the most parsimonious explanation of variance in pain. METHODS Psychometric assessment included McGill Pain Questionnaire, Gene...
Odors of biological relevance (e.g., predator odors, sex odors) are known to effectively influence basic survival needs of rodents such as anti-predatory defensiveness and mating behaviors. Research focused on the effects of these odors on rats' behavior mostly includes multi-trial paradigms where animals experience single odor exposures in subsequent, separated experimental sessions. In the pr...
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