Mononucleosis? The recent announcement by the Doctors Henle of Philadelphia of the finding of an antibody against the EB virus in the sera of all cases of infectious mononucleosis ( TM ) studied’ was the source of some excitement in immunologic, oncologic, and hematologic circles. In a prime example of serendipity, the Henles, who were testing various sera for antibody to this newly-discovered ...

Mononucleosis? The recent announcement by the Doctors Henle of Philadelphia of the finding of an antibody against the EB virus in the sera of all cases of infectious mononucleosis ( TM ) studied’ was the source of some excitement in immunologic, oncologic, and hematologic circles. In a prime example of serendipity, the Henles, who were testing various sera for antibody to this newly-discovered ...

W hile working in Uganda, a physician by the name of Denison Parson Burkitt first described the tumor that now carries his name. In 1957, Dr. Burkitt, along with his colleagues, examined a child with what appeared to be swelling along the jaw. After observing a second child with the same clinical presentation, his curiosity prompted him to study hospital records for similar cases. He found that...

We report the case of an HIV-infected young men with neuro-toxoplasmosis localized in the spinal cord. The patient received chemotherapy and immunotherapy for Burkitt lymphoma one year before. At the time of the diagnosis of toxoplasmosis, he was on prophylaxis with trimethoprim and sulfamethoxazole and in complete remission of Burkitt lymphoma. The CD4+ T cell count was 270/μl and the HIV vire...

Bone marrow macrophages containing other cells, or large pieces of other cells, represent a distinctive feature of diseases such as Hemophagocytic Lymphohistiocytosis (HLH) and Rosai-Dorfman disease. We describe a distinct variation of phagocytic histiocyte morphology, featuring histiocytes containing predominantly fragments of neutrophil nuclei. We retrospectively reviewed initial bone marrow ...

Expression of a high level of myeloperoxidase (MPO) as a sole myeloid marker in acute leukemias that express typical lymphoblastic markers is unusual. Herein we report 5 cases of MPO+, otherwise typical acute lymphoblastic leukemia (ALL) without the expression of other myeloid markers. In most cases, MPO positivity was detected in more than 20% of blasts by immunologic (flow cytometric) and enz...

The dream of all clinicians and researchers is to give their name to an illness, whatever the technique used to make the discovery. During the 20th century and the early part of the 21st century, several viruses have been identified by different procedures. Using electron microscopy, Epstein and Barr (Epstein et al., 1965) detected a Herpes virus in the lymphoid cells of a native African boy wi...