نتایج جستجو برای: burkholderia mallei

تعداد نتایج: 5991  

2013
Mary N. Burtnick Paul J. Brett

Burkholderia mallei is a facultative intracellular pathogen that causes glanders in humans and animals. Previous studies have demonstrated that the cluster 1 type VI secretion system (T6SS-1) expressed by this organism is essential for virulence in hamsters and is positively regulated by the VirAG two-component system. Recently, we have shown that T6SS-1 gene expression is up-regulated followin...

Journal: :PLoS ONE 2008
Steven E. Schutzer Linda R. K. Schlater Catherine M. Ronning David DeShazer Benjamin J. Luft John J. Dunn Jacques Ravel Claire M. Fraser-Liggett William C. Nierman

BACKGROUND Burkholderia mallei is an understudied biothreat agent responsible for glanders which can be lethal in humans and animals. Research with this pathogen has been hampered in part by constraints of Select Agent regulations for safety reasons. Whole genomic sequencing (WGS) is an apt approach to characterize newly discovered or poorly understood microbial pathogens. METHODOLOGY/PRINCIP...

Introduction Glanders is one of the oldest contagious and dangerous zoonotic diseases manifesting ulcerative granulomatous lesions on the skin and mucous membranes. Early methods possessing desirable sensitivity and specificity is important to diagnose the disease considering the just only one case report and preventing disease by identification and eradication. The present study was aimed to ...

2015
Nicole L. Podnecky Katherine A. Rhodes Herbert P. Schweizer

Several members of the genus Burkholderia are prominent pathogens. Infections caused by these bacteria are difficult to treat because of significant antibiotic resistance. Virtually all Burkholderia species are also resistant to polymyxin, prohibiting use of drugs like colistin that are available for treatment of infections caused by most other drug resistant Gram-negative bacteria. Despite cli...

2012
P Khaki N Mosavari Nasiri S Khajeh M Emam M Ahouran S Hashemi Mohammad M Taheri D Jahanpeyma S Nikkhah

BACKGROUND AND OBJECTIVES In December 2010 four, lions and one tiger died at the Tehran zoo. Out of all samples, Burkholderia mallei (causative agent of Glanders) was isolated just from ulcer sample of the tiger which was imported to Iran from Russia. MATERIALS AND METHODS One nasal swab from a tiger and fifteen blood samples with anticoagulant belonging to one tiger and fourteen lions (four ...

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