The protein Keap1 is central to the regulation of the Nrf2-mediated cytoprotective response, and is increasingly recognized as an important target for therapeutic intervention in a range of diseases involving excessive oxidative stress and inflammation. The BTB domain of Keap1 plays key roles in sensing environmental electrophiles and in mediating interactions with the Cul3/Rbx1 E3 ubiquitin li...

The mechanism(s) that regulate and coordinate the events of spermiation and blood-testis barrier (BTB) restructuring in the seminiferous epithelium that occur concurrently at stage VIII of the seminiferous epithelial cycle of spermatogenesis are unknown. In this report, fragments derived from the laminin complex composed of laminin alpha3, beta3, and gamma3 chains (laminin-333) at the apical ec...

Caveolin-1 affects the permeability of blood-tumor barrier (BTB) by regulating the expression of tight junction-associated proteins. However, the effect is still controversial. In the present work, we studied the regulative effect of caveolin-1 on the expression of tight junction-associated proteins and BTB via directly silencing and overexpressing of caveolin-1 by recombinant adenovirus transd...

The black turtle bean (BTB) is most widely consumed legume all over the world having anticancer activity. The aim of the study was to analyse the apoptotic effects of BTB extracts on human breast cancer cell lines. Plant extract was prepared by homogenization and centrifugation. The cytotoxic effects of BTB was evaluated by MTT assay and their apoptotic effects were characterized by DNA fragmen...

BACKGROUND Control of bovine tuberculosis (bTB) and zoonotic tuberculosis (zTB) has relied upon surveillance and slaughter of infected cattle, milk pasteurisation and public health education. In Cameroon, like many other sub-Saharan African countries, there is limited understanding of current cattle husbandry or milk processing practices or livestock keepers awareness of bTB. This paper describ...

The objective was to study how surveillance for bovine tuberculosis (bTB) could be made more resource-effective in a bTB free country. A stochastic scenario tree model was developed to: (1) evaluate the sensitivity (CSe) of four surveillance system components (SSC) (i.e., meat inspection of slaughtered domestic cattle, farmed deer and pigs, and tuberculin testing of adult export cattle) given t...

Multiple-stranded helicates are of interest in respect of their simplicity in geometry and significance in biology and materials. Bis-β-diketones have shown their advantage in terms of structure and geometry in the construction of multiple-stranded helicates, but further studies on their properties are limited due to their poor crystallization. In this study, solvents are found to play a decisi...

The PLZF (promyelocytic leukemia zinc finger) transcriptional repressor, when fused to retinoic acid receptor alpha (RARalpha), causes a refractory form of acute promyelocytic leukemia. The highly conserved N-terminal BTB (bric a brac, tramtrack, broad complex)/POZ domain of PLZF plays a critical role in this disease, since it is required for transcriptional repression by the PLZF-RARalpha fusi...

Bovine tuberculosis (BTB), caused by Mycobacterium bovis, is a disease that was introduced relatively recently into the Kruger National Park (KNP) lion population. Feline immunodeficiency virus (FIV(ple)) is thought to have been endemic in lions for a much longer time. In humans, co-infection between Mycobacterium tuberculosis and human immunodeficiency virus increases disease burden. If BTB we...

Penyakit Layu Bakteri merupakan penyakit tular tanah yang menyerang tanaman hortikultura disebabkan oleh bakteri fitopatogen Ralstonia solanacearum . Komunitas menghuni rizosfer diketahui memiliki potensi baik dalam mendukung pertumbuhan maupun melindungi dari serangan patogen. pembentuk endospora dipilih karena toleransi cukup bagus apabila dihadapkan dengan lingkungan tidak cocok bagi pertumb...