The optimization of a practical, catalytic, asymmetric process for the alpha-bromination of acid chlorides to produce synthetically versatile, optically active alpha-bromoesters is reported. A range of products is produced in high enantioselectivity and moderate to good chemical yields with retention of both upon scale-up. The reactions herein are catalyzed by cinchona alkaloid derivatives, wit...

The title compound, C(13)H(18)Br(2)O(3), was prepared by a bromination reaction of (1E,3Z)-methyl 5-oxocyclo-octa-1,3-diene-carboxyl-ate, which was obtained by an ep-oxy-dation reaction of tert-butyl cyclo-oct-1,3-diene-carboxyl-ate. The crystal structure confirms unequivocally the absolute configuration of both chiral centres to be S. In the crystal, C-H⋯O inter-actions link the mol-ecules int...

Background: Bromination-based methane conversion is one of the promising separate ways CH4 valorisation. Both methyl bromide/dibromomethane that are formed can be subsequently transformed into more useful compounds. SAPO-34 could also improve selectivity (S) towards bromomethane during bromination. Methods: To evaluate performance in this reaction process, influence time, temperature (T) and we...

An indole hydrazone has successfully been synthesized employing Schiff base reaction conditions starting from 4,6-dimethoxy-2,3-diphenylindole-7-carbaldehyde with hydrazine hydrate. The of this compound acetone yielded based imine compound. structure targeted was identified by mass and 1H spectroscopy along single crystal X-ray diffraction technique. Also, bromination bis-indole N-bromo succini...

We report the use of isolable primary and secondary alkylcarbastannatrane nucleophiles in site-specific fluorination reactions. These reactions occur without the need for transition metal catalysis or in situ activation of the nucleophile. In the absence of the carbastannatrane backbone, alkyltin nucleophiles exhibit no activity towards fluorination. When enantioenriched alkylcarbastannatranes ...

New bis-(oxazolyl)pyridine ligands for Ln(III) ions were prepared using a expeditious methodology from threonine and dipicolinic acid chloride. The synthetic strategy includes a dehydration step to give a bis-dehydroaminobutyric acid derivative followed by bromination and cyclization with DBU. Photophysical studies of Eu(III) and Tb(III) complexes of these ligands showed that the 2,6-bis-(oxazo...

1. METHOD FOR THE determination of hippuric acid based on the formatioll of a bromine derivative was deScrii)ed by Deniges (1). This bromine derivative has been determined in our laboratory to be Nbromobenzamide. N-bromobenzamide is the hydrolysis and bromination product of hippuric acid, being produced when hippuric acid is subjected to the Hofniann rearrangement, tile first step of which is a...