DNA insulators organize independent gene regulatory domains and can regulate interactions amongst promoter and enhancer elements. They have the potential to be important in genome enhancing and editing technologies because they can mitigate chromosomal position effects on transgenes. The orthologous genes of the Anopheles stephensi putative gypsy-like insulator protein complex were identified a...

Japanese pharmaceutical market, world's 2 nd largest in size, is traditionally renowned for its brands' domination and weakest generics share among major established economies. An in depth observation of published evidence in Japanese/English language provided closer insight into current trends in Japanese domestic legislation and pharmaceutical market development. Recent governmental intervent...

Familial intrahepatic cholestasis (FIC) comprises a group of rare cholestatic liver diseases associated with canalicular transport defects resulting predominantly from mutations in ATP8B1, ABCB11 and ABCB4. Phenotypes range from benign recurrent intrahepatic cholestasis (BRIC), associated with recurrent cholestatic attacks, to progressive FIC (PFIC). Patients often suffer from severe pruritus a...

Nations and organizations are becoming increasingly dependent on each other in the pursuit for global peace, eradication of poverty, environmental sustainability, and a healthy and meaningful work-life balance. Thus, human resource development (HRD) professionals, who are already prepared and equipped to foster environments for learning and change at the individual, team and organizational leve...

ownload onic lymphocytic leukemia deletion gene 7 (Clld7) is a candidate tumor suppressor on chromosome . Clld7 encodes an evolutionarily conserved protein that contains an RCC1 domain plus broad complex, ack, bric-a-brac (BTB), and POZ domains. In this study, we investigated the biological functions of Clld7 n in inducible osteosarcoma cell lines. Clld7 induction inhibited cell growth, decreas...

Bugün dünya üzerinde işlem yapılan tüm piyasalar için risk ve belirsizlik büyük önem arz etmektedir. Özellikle finansal piyasaların en aktif pazarları olan ülke borsalarında bu durum daha belirgin olarak görülebilmektedir. Hatta dünyanın önde gelen gerçekleşen ekonomik, politik, belirsizliklerin birçok getiri kaybına sebep olmaktadır. Bu çalışmada ise seçili gelişmiş gelişmekte ülkelerde))))) a...

The pathogenesis of malignant lymphomas remains poorly understood. Several approaches to detect the genes involved are available. Bric et al. [1] focus on the detection of tumor suppressor genes by using RNA interference of specific gene products in a known mouse model for lymphoma development. They detected more than 10 new candidate tumor suppressor genes, showing the validity of their functi...

The present work is an overview of the TraMOOC (Translation for Massive Open Online Courses) research and innovation project, a machine translation approach for online educational content. More specifically, videolectures, assignments, and MOOC forum text is automatically translated from English into eleven European and BRIC languages. Unlike previous approaches to machine translation, the outp...