Background & Aims: Nucleostemin is one of the stem cell enriched proteins which encodes a novel nucleolar GTP-binding protein found at high levels in the adult and embryonic stem (ES) cells but not in terminally differentiated cells. It is also expressed in tumor cell lines as well as in the several types of human cancers. Due to the increasing rate of breast cancer in recent years, in the pres...

BACKGROUND Tumor size is one of the most important factors in making clinical and pathological assessment of breast cancer. In the present study, we aimed to determine whether the preoperative measurement of tumor size, by imaging modalities, deviate from the postoperative pathological measurement in breast cancer. PATIENTS AND METHODS 1296 patients diagnosed with invasive ductal breast carci...

Metformin, a Type II diabetic treatment drug, which inhibits transcription of gluconeogenesis genes, has recently been shown to lower the risk of some diabetes-related tumors, including breast cancer. Recently, "cancer stem cells" have been demonstrated to sustain the growth of tumors and are resistant to therapy. To test the hypothesis that metformin might be reducing the risk to breast cancer...

Background: Menstrual characteristics may serve as surrogate measures of endogenous estrogen and may be related to breast cancer risk. This case-control study investigated the relationship between menstrual factors and risk of breast cancer incidence in Iranian Center for Breast Cancer (ICBC). Materials and Methods: Forty seven Cases of breast cancer referred to ICBC and 77 controls were studie...

The justification for reduction mammaplasty should be based on the probability of relieving the clinical signs and symptoms of symptomatic breast hypertrophy. Because it is difficult to determine the size at which breast enlargement becomes pathologic in any individual, it is the position of the American Society of Plastic Surgeons that the definition of symptomatic breast hypertrophy should fo...

The purpose of this study is to define prognostic relationships between computer-derived nuclear morphological features, lymph node status, and tumor size in breast cancer. Computer-derived nuclear size, shape, and texture features were determined in fine-needle aspirates obtained at the time of diagnosis from 253 consecutive patients with invasive breast cancer. Tumor size and lymph node statu...

Background: In this study, we sought to investigate if computer-extracted magnetic resonance imaging (MRI) phenotypes of breast cancer could replicate human-extracted size and Breast Imaging-Reporting and Data System (BI-RADS) imaging phenotypes using MRI data from The Cancer Genome Atlas (TCGA) project of the National Cancer Institute. Methods: Our retrospective interpretation study involved a...

Background: Breast cancer is the most common cancer found in women, and screening is the best way to make an early diagnosis. The aim of this study was to determine the rate of screening mammography and related variables in the mammography center of Mousavi Hospital, located in Zanjan, Iran. Methods: This was a prospective descriptive study. Study sample size was 526 women who were selected by...