The incidence of breast cancer in Japan has been gradually increasing (1, 2). Although the age at which women are most susceptible to breast cancer is lower than that for other cancers (3), the 5-year posttreatment survival rate in breast cancer is favorable in comparison to that in many other cancers. Thus, the prognosis of patients with breast cancer is relatively good. Therefore, patients’ p...

BACKGROUND In early breast cancer, variations in local treatment that substantially affect the risk of locoregional recurrence could also affect long-term breast cancer mortality. To examine this relationship, collaborative meta-analyses were undertaken, based on individual patient data, of the relevant randomised trials that began by 1995. METHODS Information was available on 42,000 women in...

PURPOSE There is a need to investigate the type, duration, frequency, and intensity of physical activity that are critical to reduce the risk of breast cancer, and if this relation differs among subgroups of women. METHODS We analyzed the relation between physical activity and breast cancer incidence between 1990 and 2002 (n=3,424 cases), among 90,509 women of the French E3N cohort, ages betw...

BACKGROUND Reductions in the dose intensity (DI) of adjuvant anthracycline-based chemotherapy in early stage breast cancer are frequently required due to treatment toxicity or poor tolerance, but the implications of a minimal reduction in DI on clinical outcome remain uncertain. PATIENTS AND METHODS Women with stage I-II breast cancer treated with adjuvant adriamycin and cyclophosphamide (AC)...

BACKGROUND Little data exist on the safety of elective breast surgery following breast conservation therapy. OBJECTIVES The authors evaluate their experience performing reduction mammaplasties and mastopexies in previously irradiated breasts. METHODS A retrospective chart review was conducted of all reduction mammaplasties and mastopexies in previously irradiated breasts performed by the 2 ...

BACKGROUND While the question of whether the trials of breast cancer screening have resulted in a reduction in breast cancer death has been the subject of much scrutiny, there has been less attention to the reduction in tumor size achieved by screening. METHODS Size data for invasive breast tumors were assembled from a variety of sources. The health consequences that can be expected from find...

A recent survey found that the inferior pedicle, inverted-T skin pattern is still the most common breast reduction technique used among U.S. plastic surgeons.1 This technique has been widely taught in North America and is familiar to most American plastic surgeons. Using the skin markings of this technique, the glandular excess, skin envelope, and nipple position may be readily and reliably add...

BACKGROUND Lower T-junction wound dehiscence following breast reduction surgery or mastopexy constitutes a vexing and grievous complication both to the surgeon and the patient. Treatment modalities that can expedite wound healing and reepithelialization rates are highly craved. The objective of this study was to assess wound healing and epithelialization rates of open wounds following breast re...

BACKGROUND After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year ...