The purpose of this planning case report is to share the perceived dosimetric benefits of innovative hybrid volumetric modulated arc therapy (h-VMAT) for bilateral breast cancer radiotherapy in two patients with synchronous bilateral breast cancer. Two patients with early bilateral breast cancer after breast conservation surgery and adjuvant chemotherapy were planned for bilateral breast radiot...

introduction: acoustic transient cavitation is the primary mechanism of sonochemical reaction and has potential use for tumor treatment. in this study, the in vivo anti-tumor effect of simultaneous dual-frequency ultrasound at low-level intensity (isata < 6 w/cm2) was investigated in a spontaneous murine model of breast adenocarcinoma in balb/c mice. materials and methods: forty tumor bearing m...

Abstract Background The aim of this study was to investigate whether the PAM-50-based 46-gene assay carries prognostic value for risk local recurrence breast cancer. Methods Austrian Breast and Colorectal Cancer Study Group (ABCSG) 8 RCT compared 5 years tamoxifen with 2 followed by anastrozole 3 in postmenopausal women endocrine receptor-positive This included patients from trial who had breas...

Background. Radiotherapy after breast conserving surgery increases local control. Standard radiotherapy includes whole breast irradiation delivered in a daily fashion over 5 or 51⁄2 weeks. All patients may not require entire breast treatment. We tested the feasibility of limited surgery with limited irradiation using interstitial brachytherapy to the tumor bed in a selected group of patients wi...

Most patients undergoing breast conservation therapy receive radiotherapy in the supine position. Historically, prone breast irradiation has been advocated for women with large pendulous breasts in order to decrease acute and late toxicities. With the advent of CT planning, the prone technique has become both feasible and reproducible. It was shown to be advantageous not only for women with lar...

Breast cancer outcomes continue to improve, with 5-year survival rates having increased from 50% in the 1970s to nearly 80% today. The reasons for the improvement are multifactorial, with major contributions made by the advent of screening and improved systemic therapies such as anti-oestrogens, chemotherapy and trastuzumab. Running alongside this improvement in breast-cancer-specific survival ...

Neoadjuvant treatment of breast cancer has become established as the safe and often effective therapeutic approach of choice for larger primary and for locally advanced breast cancer. The neoadjuvant approach offers the advantages of downstaging the disease, potentially reducing the extent of surgery and in an era of individualization of therapy, testing the efficacy of therapy administered to ...