A 37-year-old woman presented to the Internal Medicine Clinic with complaints of abdominal pain and constipation which had begun 3 months earlier. A colonoscopy was performed, and wall thickening of the sigmoid colon was detected. A biopsy of the sigmoid colon revealed a poorly differentiated, mucin-producing adenocarcinoma with a signet-ring pattern. No distant metastasis was detected. The pat...

Epidemiological studies have provided convincing evidence that obesity increases the risk for cancers of the oesophagus (adenocarcinoma), colon, pancreas, breast (post-menopausal), endometrium and kidney. The magnitude of the increase in risk varies between cancer sites. For an increase in BMI of 10 kg/m2 relative risks are approximately 2.3 for adenocarcinoma of the oesophagus, 1.5 for colon c...

A case of metastasis of breast adenocarcinoma into the internal auditory canal (IAC) and cerebellopontine angle (CPA) is presented, which appeared 16 years after primary tumor had been treated by surgery and radiation therapy. The 66-year old patient was considered cured from the primary disease, when she started with a rapidly developing hearing loss and intermittent facial palsy. Magnetic res...

AIM Breast cancer (BC) is one of the most common forms of cancer amongst females. Early diagnosis, prognosis and therapy plays crucial role in the survival of patients with breast cancer. The study was aimed on identification of potential markers for early BC diagnostics by means of genome-wide comparative analysis of gene expression in cancer and normal tissue of breast. METHODS The analysis...

Esophageal cancers are among the most prevalent malignancies worldwide, with high rates of incidence and mortality (Ferlay et al., 2010; Spechler et al., 2011). There are two major histological types of esophageal carcinoma: esophageal squamous cell carcinoma (ESCC) and adenocarcinoma with considerably varied epidemiological features. ESCC continues to be the major type of esophageal cancer in ...

In the present study, a set of 2-anilino-4-alkylaminoquinazoline derivatives were synthesized and tested for their antitumor activities in vitro against panel four human cancer cell lines DNA-binding affinity. Among compounds, 4c 5b with 4-substitution at phenyl ring found to have highest inhibitory effects breast adenocarcinoma (MCF-7), colon (HCT-116), hepatocellular carcinoma (HePG-2), skin ...

Herbs and spices have been traditionally used for prevention and cure of many diseases. Hence, the present study was aimed to investigate the effects of aqueous and alcoholic extract of four different spices (asafoetida, ginger, cinnamon and cardamom) extracts on human breast adenocarcinoma cell line (MCF) and HEP-G2 cancer cell lines through in-vitro growth inhibitory assay. Both aqueous and a...

This study presents a method based on carpet bombardment of immobilized cells with cavitating flows. For this, cancer cell lines are exposed to micro scale flows from the tip nozzle under effect cavitation microbubbles. The deformation as result bubbles differs one type another. Therefore, difference in upon exposure (carpet bombardment) acts valuable indicator for diagnosis. developed system i...

Purpose: To evaluate the relevance between lumican expression patterns and the clinical course of patients with pancreatic ductal adenocarcinoma (PDAC), and to investigate the role of lumican in PDAC

Krajewski et al. (1 ) have recently analyzed the relationship between p53 immunoreactivity and the level of Bcl-2 and Bax in breast cancers using immunohistochemistry, because recent data indicate that wild-type p53 can transcriptionally repress Bcl-2 expression while inducing the expression of Bax. Absence of p53 in knockout mice was associated with increased Bcl-2 and decreased Bax in some ti...