نتایج جستجو برای: brca2 gene promoter

تعداد نتایج: 1174704  

2015
Margret Aradottir Sigridur T Reynisdottir Olafur A Stefansson Jon G Jonasson Asgerdur Sverrisdottir Laufey Tryggvadottir Jorunn E Eyfjord Sigridur K Bodvarsdottir

Overexpression of the Aurora A kinase has been shown to have prognostic value in breast cancer. Previously, we showed a significant association between AURKA gene amplification and BRCA2 mutation in breast cancer. The aim of this study was to assess the prognostic impact of Aurora A overexpression on breast cancer arising in BRCA2 mutation carriers. Aurora A expression was evaluated by immunohi...

Journal: :Blood 2011
Kajal Biswas Ranabir Das Blanche P Alter Sergey G Kuznetsov Stacey Stauffer Susan L North Sandra Burkett Lawrence C Brody Stefan Meyer R Andrew Byrd Shyam K Sharan

Biallelic mutations in the human breast cancer susceptibility gene, BRCA2, are associated with Fanconi anemia, implying that some persons who inherit 2 deleterious variants of BRCA2 are able to survive even though it is well established that BRCA2 is indispensable for viability in mice. One such variant, IVS7 + 2T > G, results in premature protein truncation because of skipping of exon 7. Surpr...

Journal: :Cancer research 1999
I Bièche R Lidereau

The breast cancer susceptibility gene BRCA2 is expressed in a wide range of tissues as an 11-kb mRNA transcript encoding a 3418-amino acid protein, which is involved in the response to DNA damage. To obtain a better molecular characterization of BRCA2 expression in breast tissue, we analyzed full-length BRCA2 mRNA by means of reverse transcriptase-PCR with a panel of primer pairs encompassing t...

Journal: :The Journal of biological chemistry 2006
Hiroyuki Kitao Kazuhiko Yamamoto Nobuko Matsushita Mioko Ohzeki Masamichi Ishiai Minoru Takata

A rare hereditary disorder, Fanconi anemia (FA), is caused by mutations in an array of genes, which interact in a common FA pathway/network. These genes encode components of the FA "core" complex, a key factor FancD2, the familial breast cancer suppressor BRCA2/FancD1, and Brip1/FancJ helicase. Although BRCA2 is known to play a pivotal role in homologous recombination repair by regulating Rad51...

Journal: :modares journal of medical sciences: pathobiology 2006
mastaneh zohri majid sadeghizadeh khosro khajeh hadi shirzad

current investigations indicate different in vitro infection patterns for oka and dumas strains. infection of cells in culture with dumas strain produces lower number of infectious particles while the oka strain is highly infectious in vitro. it is postulated that weak expression of the replication genes in dumas strain may be the reason for the attenuated phenotype. the objective of this stud...

2011
Adriana Rodríguez-Marí Catherine Wilson Tom A. Titus Cristian Cañestro Ruth A. BreMiller Yi-Lin Yan Indrajit Nanda Adam Johnston John P. Kanki Erin M. Gray Xinjun He Jan Spitsbergen Detlev Schindler John H. Postlethwait

Mild mutations in BRCA2 (FANCD1) cause Fanconi anemia (FA) when homozygous, while severe mutations cause common cancers including breast, ovarian, and prostate cancers when heterozygous. Here we report a zebrafish brca2 insertional mutant that shares phenotypes with human patients and identifies a novel brca2 function in oogenesis. Experiments showed that mutant embryos and mutant cells in cult...

Journal: :Cancer Cell International 2021

Abstract Background Our previous study shows that LINC01278 inhibits the malignant proliferation and invasion of papillary thyroid carcinoma (PTC) cells by regulating miR-376c-3p/DNM3 axis. However, regulation mechanism expression in PTC is still unclear. Methods The luciferase reporter ChIP assays were used to confirm binding LEF-1 putative promoter site gene. RNA immunoprecipitation pulldown ...

Journal: :The EMBO journal 2004
Nicolas Siaud Eloïse Dray Isabelle Gy Emmanuelle Gérard Najat Takvorian Marie-Pascale Doutriaux

Two BRCA2-like sequences are present in the Arabidopsis genome. Both genes are expressed in flower buds and encode nearly identical proteins, which contain four BRC motifs. In a yeast two-hybrid assay, the Arabidopsis Brca2 proteins interact with Rad51 and Dmc1. RNAi constructs aimed at silencing the BRCA2 genes at meiosis triggered a reproducible sterility phenotype, which was associated with ...

Journal: :Human molecular genetics 1997
G Bignell G Micklem M R Stratton A Ashworth R Wooster

The breast cancer susceptibility gene BRCA2 encodes a protein of 3418 amino acids which does not exhibit substantial sequence similarity to any other protein in the public databases. A dot matrix comparison of BRCA2 with itself revealed an eight times repeated motif in the segment of the protein encoded by exon 11. As a preliminary test of the hypothesis that these motifs are functionally signi...

E Khateri, P Afsharian R Aflatoonian R Favaedi

Background Cytochrome aromatase p450, encoded by the gene CYP19A1, is a key enzyme for estrogen biosynthesis. Among the multiple promoters of CYP19A1, the proximal promoter PII is the most active ones in ovary and endometrium. Endometriosis is a chronic estrogen dependent gynecological condition characterized by the presence of ectopic glands and stroma outside the uterine cavity. Recently, evi...

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