MicroRNA expression can be exploited to define tumor prognosis and stratification for precision medicine. It remains unclear whether prognostic microRNA signatures are exclusively tumor grade and/or molecular subtype-specific, or whether common signatures of aggressive clinical behavior can be identified. Here, we defined microRNAs that are associated with good and poor prognosis in grade III a...

BACKGROUND AND PURPOSE Optimizing high-grade glioma treatment requires the delineation of edematous and normal brain from tumor, perhaps by using potential differences in the absolute diffusion parameters of water. Our purpose was to determine whether mean diffusivity and diffusion anisotropic MR imaging data help in this differentiation. METHODS Nine patients with high-grade cerebral gli...

background and purpose: cancer and cerebrovascular accidents (cva) are two most common causes of mortality and morbidity in the elderly. patients with brain tumor can be highly affected by postsurgical stroke. cva may be the first manifestation in these patients . therefore, we aimed to assess the epidemiological factors affecting cva after brain surgery. methods: in this cross-sectional study ...

PURPOSE The purpose of this research was to perform a preliminary assessment of protein patterns in primary brain tumors using a direct-tissue mass spectrometric technique to profile and map biomolecules. EXPERIMENTAL DESIGN We examined 20 prospectively collected, snap-frozen normal brain and brain tumor specimens using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS...

Around the world, brain tumors are becoming leading cause of mortality. The inability to undertake a timely tumor diagnosis is primary this pandemic. Brain cancer crucial procedure that relies on expertise and experience doctor. Radiologists must use an automated classification model find cancers. current model’s accuracy has be improved get suitable therapies. can consult various computer-aide...

The BraTS dataset contains a mixture of high-grade and low-grade gliomas, which have rather different appearance: previous studies shown that performance can be improved by separated training on gliomas (LGGs) (HGGs), but in practice this information is not available at test time to decide model use. By contrast with HGGs, LGGs often present no sharp boundary between the tumor core surrounding ...

Brain tumors are associated to more than 50% of patients with epilepsy, of which about 30% are drug-resistant. Epilepsy associated with brain tumors is multifactorial, but fundamentally depends on its location and histology. So, low-grade tumors are more epileptogenic than high-grade. In high-grade tumors and adult epilepsy is associated with increased frequency of neurological deficits. In low...

The presence of IOT-10-positive lymphocytes among the tumor-infiltrating-lymphocyte (TIL) population was studied in a series of 185 brain tumors. In most of the tumors, IOT-10-positive lymphocytes were identified, but generally they were scarce and masked among the tumor cells, suggesting that NK-cells exercise a poor participation in the tissular response against brain tumors. Isolated tumor c...

breast cancer is the most common cause of cancer-related death in female, after lung cancer. angiogenesis is essential for tumor growth and metastasis; therefore, antiangiogenesis strategies for treatment of cancer are currently an issue of interest. the role of vascular endothelial growth factor that assumed to be most potent angiogenesis factor is ambiguous in breast cancer. this study descri...

background: gliomas are the most common primary neoplasms of the central nervous system. relative cerebral blood volume (rcbv) could estimate high-grade gliomas computed with dynamic susceptibility contrast mr imaging which it is artificially lowered by contrast extravasation through a disrupted blood-brain barrier. objectives: our intent was to clarify the usefulness of diffusion-weighted magn...