Biallelic inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene predisposes human patients to the development of highly vascularized neoplasms in multiple organ systems. We show that zebrafish vhl mutants display a marked increase in blood vessel formation throughout the embryo, starting at 2 days post-fertilization. The most severe neovascularization is observed in distinct areas t...

Germ-line p53 mutations are associated with dominantly inherited Li-Fraumeni syndrome (LFS), which features early-onset sarcomas of bone and soft tissues, carcinomas of the breast and adrenal cortex, brain tumors, and acute leukemias. However, carriers of germ-line p53 mutations may also be at increased risk of other cancers. To clarify the tumor spectrum associated with inherited p53 mutations...

Central nervous system neoplasms include diverse group of tumors with a wide spectrum of morphologies, tissues of origin, histologic subtypes and molecular abnormalities. Despite their relatively rare occurrences, these tumors can result in considerable mortality as well as morbidity. Depending on their tissue of origin, these neoplasms can be broadly divided into glial and non-glial tumors. Pr...

This article discusses three current medical and environmental problems that use microwave technologies to solve. The first task was related the influence of magnetic field on human body. At same time, special attention paid its deficiency, which leads undesirable consequences need for correction. second diagnosis therapy brain tumors. results studies possibility virtual diagnostics cerebral ed...

Sarcomatoid squamous cell carcinomas are extremely rare, high grade, aggressive variant of penile cancers. Sarcomatoid carcinoma are biphasic neoplasms with a combination of both sarcomatoid components and carcinomatous elements. These neoplasms are very rare in the urogenital system. We report a 53-year-old male presented with an ulcerated lesion on the glans penis. The rarity of this case rei...