Uterine cervical cancer usually spreads by local extension and through the rich lymphatic network to retroperitoneal lymph nodes. However, brain metastasis from primary is extremely rare. They are seen late in clinical course have poor prognosis. We present a52-year-old woman with squamous cell carcinoma of cervix who developed other multiple metastases after 8-month treatment disease. The pati...

Colorectal cancer is one of the most common digestive tract malignancies in the world. Owing to the newer and more effective systemic therapies, the life of colorectal cancer patients can be remarkably prolonged, and the incidence of brain metastases is increasing. However, little is known about the underlying mechanisms of brain metastasis from colorectal cancer. Here we review the tumor micro...

Two unusual cases of brain metastasis from hepatocellular carcinoma (HCC) are described. A 15-year old boy presented with intracerebral hemorrhage from brain metastasis from HCC, and died of rebleeding 1 month after surgery. Cerebral metastatic HCC in a child is quite rare, and has not previously been reported. A 65-year-old male with a 2-year history of treatment for HCC presented with a brain...

OBJECTIVE To determine the incidence and risk factors for leptomeningeal metastasis after surgery for brain metastasis of solid tumors. METHODS Review of the records of all patients operated on for brain metastasis between January 1990 and August 1995. RESULTS In this period 28 patients underwent surgery for brain metastasis, of whom 27 were available for evaluation in this study. Median su...

introduction : pulmonary adenosquamous carcinoma is an uncommon histological variety of bronchogenic carcinoma, and has histologic areas differentiated as both squamous cell carcinoma and adenocarcinoma and has clinical behavior more like that of adenocarcinoma. tumor stage is higher at the time of diagnosis, and survival is poorer. case presentation : we present a 65 years old woman with bulgi...

BACKGROUND It is estimated that at least 200 000 cases of brain metastases occur each year in the US, which is 10 times the number of patients diagnosed with primary brain tumors. Brain metastasis is associated with poor prognosis, neurological deterioration, diminished quality of life, and extremely short survival. Favorable interactions between tumor cells and cerebral microvascular endotheli...

We investigated the molecular mechanisms of angiogenesis in experimental brain metastasis. Cells from six different human cancer cell lines (proven to produce visceral metastasis) were injected into the internal carotid artery of nude mice. Colon carcinoma (KM12SM) and lung adenocarcinoma (PC14PE6 and PC14Br) cells produced large, fast-growing parenchymal brain metastases, whereas lung squamous...