The burden [as defined by the World Health Organisation (WHO)] of brain diseases (neurological, neurosurgical and psychiatric diseases together) is very high and yet resources spent on these diseases are not necessarily commensurate with the extent of this burden. However, hard data on the burden of brain diseases in Europe have not previously been easily accessible. The Global Burden of Diseas...

The primary aim of this research is to design a Fuzzy Inference System for diagnosing brain diseases. The design was carried out with MATLAB software using the Mamdani inference method. The scope of the work is extended to five brain diseases, namely Alzheimer’s disease, Creutzfeldt Jakob disease, Huntington’s disease, Multiple Sclerosis and Parkinson’s disease. The system has four input variab...

Background: Brain ischemic disorders are common diseases of neural systems. One of the predisposing factors affect to the brain ischemia is systemic hypertension. The aim of this study was the determination of relation between blood pressure and spread of brain ischemia in CT scan in brain ischemia patients. Materials & Methods: In the first stage and on the basis of research group, we selecte...

The blood-brain barrier (BBB) is formed by continuous, closely connected endothelial cells, enveloped in the basal lamina, pericytes, and foot extensions of astrocytes. BBB has a vital role brain metabolism protects parenchyma from harmful agents present systemic circulation. Damage to an increase its permeability have important many neurodegenerative diseases. This paper aims review literature...

With the increment of aging population in recent years, neurodegenerative diseases exert a major global disease burden, essentially as result lack treatments that stop progression. Alzheimer’s Disease (AD) is an example affects millions people globally, with no effective treatment. Natural compounds have emerged viable therapy to fill huge gap AD management, and mostly fueled by COVID-19 pandem...

Brain state varies from moment to moment. While brain can be defined by ongoing neuronal population activity, such as oscillations, this is tightly coupled with certain behavioural or vigilant states. In recent decades, abnormalities in have been recognised biomarkers of various diseases and disorders. Intriguingly, accumulating evidence also demonstrates mutual interactions between states dise...

The increase in people’s longevity has, consequently, led to more brain involvement and neurodegenerative diseases, which can become complicated lead chronic degenerative thereby presenting greater public health problems. Medicinal plants have been used since ancient times contain high concentrations of molecules, including polyphenols. It has proven that polyphenols, are present various natura...

traumatic brain injury (tbi) is one of the most common neurological diseases with no definite treatment. erythropoietin (epo) and progesterone (prog) have been shown to have neuroprotective effects in different types of experimental brain injury models. this study was designed to determine the effect of epo, prog and combination of epo/prog on neurological outcome after traumatic brain injury. ...

The link between nutrition and human diseases has always been recognized, but only with modern molecular genetic analysis tools, the role of gut microbiome including gastrointestinal tract function on neurodegenerative become obvious. Gut microbiota significantly influences metabolic immune responses host organism, thus, dietor infection-related imbalances (dysbiosis) disrupt local systemic hom...

The blood-brain barrier (BBB) is a multicellular neurovascular unit that serves as highly impermeable cellular to regulate brain homeostasis, protect the central nervous system, and respond different physiological pathological states. Recently, new drugs have been discovered treat neuropathology. However, because BBB blocks delivery of system (CNS), it still difficult translate treatment CNS di...