The aim of the study was to develop, synthesis, and characterise a novel 1,3,5-trisubstituted-2-pyrazolines derivative, as well evaluate its antifungal activity. reaction chalcone derivatives with succinic hydrazide in presence pyridine yielded 1,3,5-tri-substituted-2-pyrazolines derivatives. Total 20 compounds has been synthesized characterized by IR, 1HNMR mass spectral analysis. Antifungal a...

AIMS Post-infarction remodelling (PIR) determines left-ventricular (LV) function and prognosis after myocardial infarction. The aim of this study was to evaluate transthoracic ultrasound-mediated microbubble stimulation (UMS) as a novel gene- and cell-free therapeutic option after acute myocardial infarction and reperfusion (AMI/R) in mice. METHODS AND RESULTS For myocardial delivery of UMS, ...

The digold complex [Au2(l-G)(l-dmpe)](KBr)0:75 2H2O (dmpe1⁄4 1,2-bis(dimethylphosphino)ethane (1)) has been prepared by nucleophilic attack of the guaninate dianion on the gold(I) atoms of [(AuBr)2(l-dmpe)] and has been characterised by X-ray crystallography and spectroscopic studies. The structure of 1 consists of dinuclear nine-membered ring molecules, Kþ cations, Br anions and water molecule...

The N termini of the capsid proteins VP1 and VP2 of adeno-associated virus (AAV) play important roles in subcellular steps of infection and contain motifs that are highly homologous to a phospholipase A(2) (PLA(2)) domain and nuclear localization signals (NLSs). To more clearly understand how virion components influence infection, we have generated mutations in these regions and examined their ...

We evaluated the safety and feasibility of breast cancer vaccine therapy using a new cell line, SV-BR-1, in conjunction with repeated injections of GM-CSF, as a prototype for a subsequent genetically engineered vaccine. Also addressed with this preliminary trial were monitoring effects on quality of life, screening for potential immune responses, and evaluating any clinical effects on tumor pro...

resistance of 16 sugar beet cultivars to cercospora leaf spot was evaluated in ghaemshahr region. the experiment was conducted in a complete block design with 6 replications, and, disease severity of cultivars was measured two times. root yield of cultivars, as well as their disease severity, was compared with each other under natural cercospora infection in dezful area (winter crop). in dezful...