OBJECTIVES/HYPOTHESIS To assess the comparative effectiveness of botulinum toxin and propranolol in patients with essential vocal tremor (EVT). STUDY DESIGN Individual prospective cohort study. METHODS Study patients were recruited at the Emory Voice Center from patients seeking treatment for EVT. Exclusion criteria included current β-blocker treatment, spasmodic dysphonia, or other disease...

BACKGROUND Botulinum toxin is a neurotoxin produced by the bacterium Clostridium botulinum which causes a flaccid muscle paralysis. It is currently used for aesthetic treatments and in the focal hyperhidrosis. Recently, botulinum toxin has also been used experimentally in many other dermatological conditions with good results. OBJECTIVE To review and analyze the possible botulinum toxin off-l...

BACKGROUND Botulinum toxin blocks acetylcholine release from nerve endings and acts as a long term, reversible inhibitor of muscle contraction as well as of salivary, sweat gland, adrenal and prostatic secretions. The aim of the present study is to investigate whether gastric submucosal injection of botulinum toxin type A reduces stimulated gastric production of HCl. METHODS Sixty-four rats w...

OBJECTIVE To determine the efficacy of intradetrusor injections of botulinum toxin A for non-neurogenic urinary urge incontinence. METHODS We conducted a six-month, randomized, double-blind controlled trial involving women with urinary urge incontinence. Participants received intradetrusor injections of either botulinum toxin (100U in 10 mL) via cystoscopy or a placebo control (saline injecti...

OBJECTIVE The aim of this study was to investigate the influence of different volumes of saline vehicle on the effects of botulinum toxin type A in reducing ankle plantarflexor spasticity and improving gait pattern in children with cerebral palsy. DESIGN Children with cerebral palsy having ankle plantarflexor spasticity were recruited. They were divided randomly into 2 groups. Botulinum toxin...

Cleveland, Ohio Background: The objective of the study was to determine whether botulinum toxin type A injections can serve as a prognosticator for migraine surgery success. Methods: Patients who underwent migraine surgery from 2000 to 2010 by the senior author (B.G.) were reviewed. Patients were included if they had botulinum toxin type A injection before surgery; had completed postinjection, ...

Aesthetic practitioners prefer various reconstitution volumes for botulinum toxins (BoNTAs). Some injectors prefer larger volumes of bacteriostatic normal saline (NaCl) to achieve a larger diffusion in certain areas and a smaller volume for more precise administration of the BoNTA. Some practitioners believe dilution volumes do not matter at all in relation to spread or diffusion, asserting the...

BACKGROUND Botulinum toxin A has been used increasingly in the treatment of focal hyperhidrosis. OBJECTIVE To assess the long-term efficacy of botulinum toxin A in the treatment of hyperhidrosis and the changes in quality of life and patient satisfaction with treatment. METHODS A questionnaire was designed to assess the efficacy using visual analog scales and the quality of life both before...

The article provides general information on botulinum therapy in treating spastic forms of cerebral palsy; a review of modern botulinum toxin A drugs’ injection precision control methods at spasticity and other pathologic states is given; advantages and disadvantages of each injection control method are analyzed in detail. Special attention is paid to the substantiated choice of the injection c...

BACKGROUND Botulinum toxin type A treatment has been used for over 20 years to enhance the appearance of the face. There are several commercially available botulinum toxin type A products used in aesthetic clinical practice. The aim of this retrospective analysis was to compare the clinical efficacy of the most commonly used botulinum toxin type A preparations in daily practice. METHODS Physi...