Advances in marker technology have made a dense marker map a reality. If each marker is considered separately, and separate tests for association with a disease gene are performed, then multiple testing becomes an issue. A common solution uses a Bonferroni correction to account for multiple tests performed. However, with dense marker maps, neighboring markers are tightly linked and may have ass...

Genome-wide association studies often involve testing hundreds of thousands of single-nucleotide polymorphisms (SNPs). These tests may be highly correlated because of linkage disequilibrium among SNPs. Multiple testing correction ignoring the correlation among markers, as is done in the Bonferroni procedure, can cause loss of power. Several multiple testing adjustment methods accounting for cor...

knowing income inequality in socio-economic subgroups helps us to achieve justice. the main goal of this study is to evaluate, decompose and compare the theil and atkinson inequality indices in terms of the inequality within and inequality between urban and rural area in tehran province during the 3rd and the 4th economic development program of iran. doing so, we used the micro households'...

Often, the reader of a published paper is interested in a comparison of parameters that has not been presented. It is not possible to make inferences beyond point estimation since the standard error for the contrast of the estimated parameters depends upon the (unreported) correlation. This study explores approaches to obtain valid confidence intervals when the correlation [Formula: see text] i...

OBJECTIVE To volumetrically evaluate soft tissue changes of different ridge preservation techniques compared to spontaneous healing 6 months after tooth extraction. MATERIALS AND METHODS In each of 40 patients, one single-rooted tooth was extracted and four treatment modalities were randomly assigned to the following groups (n = 10 each): A) ß-tricalcium-phosphate-particles with a polylactid ...

OBJECTIVE To assess the efficacy of tranexamic acid or mefenamic acid in the management of the initial "nuisance" bleeding or spotting in the period immediately after placement of the levonorgestrel-releasing intrauterine system. METHODS Women were randomized after levonorgestrel-releasing intrauterine system placement to oral tranexamic acid (500 mg), mefenamic acid (500 mg), or placebo thre...

Statistical analysis of a data set typically involves testing not just a single hypothesis, but rather many (often very many!). For any particular test, we may assign a pre-set probability α of a type-1 error (i.e., a false positive, rejecting the null hypothesis when in fact it is true). The problem is that using a (say) value of α = 0.05 means that roughly one out of every twenty such tests w...

PURPOSE The purpose of this study was to pilot test our study procedures and estimate parameters for sample size calculations for a randomized controlled trial to determine if bilateral sacroiliac (SI) joint manipulation affects specific gait parameters in asymptomatic individuals with a leg length inequality (LLI). METHODS Twenty-one asymptomatic chiropractic students engaged in a baseline 9...

The papers in the series are intended for internal use and are distributed by the author. Copies may be ordered from the library of Depertment of Computer Science. Abstract| In simulation studies the focus has traditionally been on time-independent characteristics of queueing systems , particularly on the steady-state mean. The systems, even if they are in stochastic equilibrium, have also time...

This note presents three ways of constructing simultaneous condence intervals for linear estimates of linear functionals in inverse problems, including \Backus-Gilbert" estimates. Simultaneous con dence intervals are needed to compare estimates, for example, to nd spatial variations in a distributed parameter. The notion of simultaneous con dence intervals is introduced using coin tossing as an...