Background: Total hip arthroplasty (THA) is a common procedure that increasingly being performed in younger patients. Deep acetabular reaming will result more bone loss and the need for large components to be implanted. It can also lead impingement, loosening, an altered center of rotation, intraoperative periprosthetic fracture. The purpose this study determine whether single ream, robotic arm...

Introduction: The demand for joint replacements in young patients is increasing, and therefore there is a need to increase the lifetime of the prostheses. To fulfil this requirement, new replacements’ designs and materials are being introduced. One of the design parameters that may affect wear of total knee replacements, and hence the predicted lifetime of such prostheses, is the insert conform...

Introduction: Racial minorities, including Black and Hispanic populations, suffer more postoperative hip surgery complications relating to fixations replacements than White populations. The goal is use CT scans 3D projections create a bone mineral density distribution model for these racial groups. Methods: A preliminary trial of the proposed methods was conducted ensure reliable data could be ...

Loosening is recognized as one of the primary sources of total hip replacement (THR) failure. In this study the influence of the bone surface texture on loosening of the cement/bone interface was studied. Model cemented hip replacements were prepared and subjected to cyclic loads that induced pure shear fatigue of the cement/bone interface. The femoral canals were textured with the use of speci...

Evolution of sequences mostly involves independent changes at different sites. However, substitutions at neighboring sites may co-occur as multinucleotide replacement events (MNRs). Here, we compare noncoding sequences of several species of primates, and of three species of Drosophila fruit flies, in a phylogenetic analysis of the replacements that occurred between species at nearby nucleotide ...

We explore a new type of replacement of patterns in permutations, suggested by James Propp, that does not preserve the length of permutations. In particular, we focus on replacements between 123 and a pattern of two integer elements. We apply these replacements in the classical sense; that is, the elements being replaced need not be adjacent in position or value. Given each replacement, the set...

Chlorofluorocarbons (CFCs) are stable in the atmosphere and may reach the stratosphere. They are cleaved by UV-radiation in the stratosphere to yield chlorine radicals, which are thought to interfere with the catalytic cycle of ozone formation and destruction and deplete stratospheric ozone concentrations. Due to potential adverse health effects of ozone depletion, chlorofluorocarbon replacemen...

A new stratified approach to pre-clinical tribological simulation of joint replacements is presented, which extends beyond present standard conditions used. It includes variations in surgical delivery, variations in kinematics, variations in the patient population and degradation of the biomaterials technology. Examples of the new methods are presented, which have been validated against clinica...

We describe a novel freely available web server Base of Bioisosterically Exchangeable Replacements (BoBER), which implements an interface to a database of bioisosteric and scaffold hopping replacements. Bioisosterism and scaffold hopping are key concepts in drug design and optimization, and can be defined as replacements of biologically active compound's fragments with other fragments to improv...