Signaling by bone morphogenetic proteins is essential for a wide variety of developmental processes. Receptor-regulated Smad proteins, Smads 1 and 5, are intracellular mediators of bone morphogenetic protein signaling. Together with Smad4, these proteins translocate to the nucleus and modulate transcription by binding to specific sequences on the promoters of target genes. We sought to map tran...

The present study was to investigate the effects of toll-like receptor 4 on transplanted bone marrow stem cells in ischemic brain. Focal cerebral ischemia induced by permanent occlusion middle artery gene knockout mice and wild type control mice. Bone were injected into lateral ventricle. cylinder tests, vivo image, polymerase chain reaction array, etc. applied evaluate neurological function un...

Bone morphogenetic protein 9 (BMP9), also known as growth differentiation factor 2 (GDF2), is a member of the transforming ? (TGF ?) superfamily. Although BMP9 plays pivotal roles during development, including angiogenesis, hematopoiesis, hepatogenesis, osteogenesis, and glucose metabolism, little information available for expression in central nervous system (CNS). We, thus, investigated adult...

Introduction: The magnesium alloy was fabricated into orthopedic plates, and used to repair tibial fractures of New Zealand white rabbits. osteogenesis degradation behavior plates were investigated in vivo. Methods: 38 rabbits randomly divided an experimental group using the plate control a titanium plate. Tibial fixed with respectively. An X-ray fracture site taken at 1, 2, 4, 8, 16 weeks afte...