OBJECTIVES The purpose of this article was to review and critically assess the use of platelet rich plasma, recombinant human bone morphogenetic protein-2 and different scaffolds (i.e. tricalciumphosphate, polycaprolactone, demineralized bone matrix and anorganic bovine bone mineral) in oral and maxillofacial surgery comparing the relevant literature and own clinical experience. MATERIAL AND ...

In the early 1980s, by determination of Boorola gene (FecB) in Booroola sheep with high ovulation rate, there has been a great interest for identification genes that are responsible prolificacy and their use breeding programs. The mutation occurred Bone morphogenetic protein 15 (BMP15), protein-1B (BMPR-1B) Growth differentiation factor 9 (GDF9) have found to increase rate. Additionally some ot...

Objective(s): The current work aimed to assess whether curcumin and baicalein can chelate iron in aplastic anemia (AA) complicated with iron overload, exploring the potential mechanisms.Materials and Methods: A mouse model of AA with iron overload complication was firstly established. Low and high-dose curcumin or baicalein treatment gro...

Title: Genetic Polymorphisms in Bone Morphogenetic Protein Receptor Type IA Gene predisposes individuals to Ossification of the Posterior Longitudinal Ligament of the Cervical Spine via the Smad signaling pathway Authors: hao wang ([email protected]) Wei Jin ([email protected]) Hai Li ([email protected]) Version: 3 Date: 27 Jan 2018 Author’s response to reviews: BMSD-D-17-00981R2 Titl...

Bone metastasis is one of the most common and severe complications in advanced malignancies, particularly in the three leading cancers; breast cancer, prostate cancer and lung cancer. It is currently incurable and causes severe morbidities, including bone pain, hypercalcemia, pathological fracture, spinal cord compression and consequent paralysis. However, the mechanisms underlying the developm...

STUDY DESIGN Review article, review of literature. OBJECTIVE To review the bone graft options that exist for posterolateral and posterior interbody lumbar fusion. SUMMARY OF BACKGROUND DATA As the number of lumbar fusion surgeries has increased over the last decade, alternative methods of grafting have been developed. Iliac crest autograft bone has traditionally been used for lumbar fusion....

In addition to changes in cellular pathways, loss of differentiation is a notable feature of osteosarcoma. We hypothesized that blocks to normal differentiation may be a common feature of osteosarcoma, and may be one of many critical events that occur during oncogenesis in osteosarcoma. Furthermore, therapies that restore normal programs of differentiation may be attractive new treatment strate...