Objective(s) Bone marrow is the traditional source of human multipotent mesenchymal stem cells (MSCs), but adipose tissue appears to be an alternative and more readily available source. In this study, rat adipose-derived stem cells (ADSCs) were induced to differentiate into Schwann-like cells and compared with rat bone marrow stem cells (BMSCs) for their Schwann-like cells differentiation pote...

In this study, we show that matrix dense cortical bone is the more potent compartment of bone than bone marrow as a stromal source for mesenchymal stem cells as isolated from adult rats. Lineage-depleted cortical bone-mesenchymal stem cells demonstrated >150-fold enrichment of colony forming unit-fibroblasts per cell incidence. compared to lineage-depleted bone marrow-mesenchymal stem cells, co...

objective: nowadays, cord blood hematopoietic stem cells (hscs) are known as a valuable source for bone marrow transplantation but unfortunately their insufficient number is a limiting factor for using them in adult bone marrow transplantation. cord blood hcss expansion is an approach to overcome this problem, by inducing their self-renewal. tgf-b signaling pathway is a key inhibitory agent for...

conclusions although the aforementioned challenges must still be addressed, the potential of wjmscs in skin regenerative clinical treatments is promising. results similar to bone marrow mscs, wjmscs express major histocompatibility complex (mhc) class i molecules. evidence acquisition according to research conducted by various researchers, wharton’s jelly mesenchymal stem cells (wjmscs) have se...

Introduction: Bone marrow (BM) is a known source of mesenchymal stem cells (MSCs) that are used for cell therapy. This study attempts to identify if the Wharton’s Jelly (WJ) is a suitable substitute for BM as a source for MSCs. Materials and Methods: A population of human WJ and BM stem cells were isolated and incubated with fluorescein conjugated antibodies for five specific MSC markers....

Abstract Although multiple studies have investigated the mesenchymal stem and progenitor cells (MSCs) that give rise to mature bone marrow, high heterogeneity in their morphologies properties causes difficulties molecular separation of distinct populations. In this study, by taking advantage resolution single cell transcriptome, we analyzed Sca-1 PDGFR-? fraction mouse marrow tissue. The transc...

osteoarthritis (oa) is a prevalent chronic disease impacting on quality of life and has societal and economical burden increasing with age. yet, no confirmed pharmacological, biological or surgical therapy could prevent the progressive destruction of oa joint. mesenchymal stem cells (mscs) with immunosuppressive activities emerged a potential therapy. we describe a magnetic resonance images (mr...

The viability of cryopreserved mouse fresh and postmortem bone marrow cells was studied using methylcellulose clonal cell culture assay and the murine spleen colony technique. This study clearly indicates the presence of pluripotent hemopoietic stem cells in cryopreserved murine postmortem bone marrow cells. The viability of granulocytic precursors in both fresh and postmortem bone marrow cells...

Aplastic anemia is a life-threatening bone marrow failure disorder characterized by peripheral pancytopenia and marrow hypoplasia. The majority of cases of aplastic anemia remain idiopathic, although hematopoietic stem cell deficiency and impaired immune responses are hallmarks underlying the bone marrow failure in this condition. Mesenchymal stem/stromal cells constitute an essential component...