1 According to the treatment of open fracture, the resurfacing of bone-exposing complex 2 wounds of Gustilo-Anderson III B and C fracture remains challenging. To treat 3 bone-exposing wounds, artificial dermis has been effective. We evaluated the 4 outcome of adapting artificial dermis the resurfacing bone-exposing complex wounds 5 of Gustilo-Anderson III B and C fracture clinically. Seven pati...

BACKGROUND To repair fractures with large bone defects or gaps, demineralized allogenic bone matrix (DBM) is often applied to the fracture site. However, studies have shown that the use of DBM alone has limited efficacy for repairing fractures. In the present study, we developed an allogenic demineralized bone powder (DBP) with basic fibroblast-derived growth factor containing a polycystic kidn...

We describe a case of radiation-associated fracture nonunion of the clavicle, which was treated by locking plate fixation and autologous bone grafting. The patient was a 67-year old man who received 70 Gy radiation therapy to treat nasopharyngeal carcinoma. Eight years later, he suffered a pathological fracture of the right clavicle. One year after the fracture, surgical treatment was performed...

Understanding the etiology of skeletal fragility during growth is critical for the development of treatments and prevention strategies aimed at reducing the burden of childhood fractures. Thus we evaluated the relationship between prior fracture and bone parameters in young girls. Data from 465 girls aged 8 to 13 years from the Jump-In: Building Better Bones study were analyzed. Bone parameters...

In some previous cases of clival bone fracture in patients with severe head injury, the diagnosis of clival bone fracture was relatively complicated. Regarding the incidence of clival fractures, some reports have shown an incidence of between 0.21% and 1.2% among traumatic brain injury victims who are admitted to hospital (1-3). The relationship between the site of the head and the type of frac...

OBJECTIVES Treatment with Sclerostin antibody (Scl-Ab) has shown to enhance fracture healing in rodent and non-human primate models. The current study investigated the time-dependent changes during Scl-Ab treatment in a mouse osteotomy model. METHODS 1 day after osteotomy, C57BL mice received subcutaneous injection with vehicle or Scl-Ab at 25 mg/kg, twice/week for 2, 4, or 6 weeks. 20 mice f...

The aim of this study was to evaluate the number and distribution of fractures around the wrist found on bone scintigraphy in patients with a clinically suspected scaphoid fracture and negative initial radiographs. We retrospectively included 445 consecutive patients with a suspected scaphoid fracture who underwent routine bone scintigraphy. None of the radiographs showed evidence of a fracture...

Background and purpose - Bisphosphonates are widely used in the treatment of bone loss, but they might also have positive effects on osteoblastic cells and bone formation. We evaluated the effect of in vivo zoledronic acid (ZA) treatment and possible concomitant effects of ZA and fracture on the ex vivo osteogenic capacity of rat mesenchymal stromal cells (MSCs). Methods - A closed femoral frac...

A safe and novel method of detection of bone fracture using ultrasound images is envisaged and presented. Presently Xrays, computed tomography (CT) and magnetic resonance imaging (MRI) are used for bone fracture detection. However, these techniques use ionizing radiation, which is harmful for both patients and medical practitioners. An alternative method for bone fracture detection which is saf...

Osteoporotic vertebral fractures represent major cause of disability, loss of quality of life and even mortality among the elderly population. Decisions on drug therapy are based on the assessment of risk factors for fracture, from bone mineral density measurements. The combination of biomechanical models with clinical studies could better estimate bone strength and support the specialists in t...