CONTEXT An increase in bone fractures has been observed in women taking thiazolidinediones. OBJECTIVE The objective of the study was to examine whether changes in circulating bone biomarkers provide insight into the underlying mechanisms responsible for the increase in bone fractures in female participants randomized to rosiglitazone in A Diabetes Outcome Progression Trial (ADOPT). RESEARCH...

BACKGROUND Ankylosing spondylitis (AS) is a chronic inflammatory disease of spine and sacroiliac joints; it is characterized by new bone formation, and the disease processes can be accompanied by osteoporosis. In the present study, we investigated changes in bone mineral density (BMD) and in the levels of various bone turnover-related biomarkers and cytokines in a cohort of AS patients, with re...

A prototype microfluidic platform has been developed for spatially and temporally resolved sampling of biomarkers expressed by organotypic tissue slices. The device draws liquid from the sample reservoir through discrete sampling ports into separate analysis microchannels. By monitoring the concentrations of specific biomarkers it is possible to map the concentration profiles of these molecules...

Long non-coding RNAs (lncRNAs) with more than 200 nuleotides, have been explored to participate in various cancer types including osteosarcoma (OS), which is the most common kind of primary bone tumors with high morbidity in infants and adolescents. These oncogenic or tumor suppressive lncRNAs regulate OS pathogenesis, such as cell growth, proliferation, invasion, migration, metastasis and cell...

Lead is a neurotoxicant that accumulates in bone with a half life of 25-30 years. To evaluate the association of lead biomarkers and cognitive function, a cohort of exposed and nonexposed workers who had been previously assessed in 1982 was retested approximately 22 years later. For the current assessment, both blood lead and tibia bone lead levels were determined. In addition, cognitive functi...

Recently, the clinical and experimental evidences that support the toxic effects of indoxyl sulfate, a protein-bound uremic toxin in chronic kidney disease (CKD) patients, has been discussed. In this panorama, the authors described several in vitro and in vivo studies, suggesting that indoxyl sulfate may play a part in the pathogenesis of low turnover bone disease. However, the discussion claim...

Rheumatoid arthritis (RA) is related to alterations in different inflammatory and connective tissue biomarkers. The diagnostic values the factors affecting these biomarkers are conflicting. In present study, a bone-related composite (B-composite), made from z-score of stromelysin-1 (MMP3), colony-stimulating factor 2 (CSF2), osteopontin (OPN), I-composite, reflecting immune activation, tumor ne...

Vitamin D deficiency is among important healthcare challenges today. Traditionally, vitamin status assessed through determination of 25-hydroxy metabolite (25(OH)D), but novel data point to 24,25(OH)2D and 25(OH)D/24,25(OH)2D ratio (VDMR) as promising biomarkers. It widely accepted that the biological role exceeds its well-known contribution bone turnover. However, effects on overall energy met...