Cellular compartments differ dramatically in their redox potentials. This translates directly into variations in the extent of disulfide bond formation within proteins, depending on their cellular localization. It has long been assumed that proteins that are present in the reducing environment of the cytosol do not possess disulfide bonds. The recent discovery of a number of cytosolic proteins ...

multiple sclerosis (ms) is a neurodegenerative and autoimmune disease that it’s molecular etiology and factors involving in its progression remains unknown. in this study for evaluation effect of mercuric on progression of ms we investigated the additive effect of mercuric sulfide on the brain mitochondrial dysfunction in experimental autoimmune encephalomyelitis (eae) model of ms in c57bl/6 mi...

We present a microscopic model for metastable Si dangling-bond defect creation in hydrogenated amorphous silicon, which is applicable to both light-induced defect creation in solar cells ~Staebler-Wronski effect! and bias-stress-induced defect creation in thin-film transistors. Light or gate bias causes electron-hole pairs or electrons, respectively, to be localized on short, weak Si-Si bonds, ...

Activated neutrophils aggregate in a shear field via bonding of L-selectin to P-selectin glycoprotein ligand-1 (PSGL-1) followed by a more stable bonding of LFA-1 (CD11a/CD18) to intercellular adhesion molecule 3 (ICAM-3) and Mac-1 (CD11b/CD18) to an unknown counter receptor. Assuming that the Mac-1 counter receptor is ICAM-3-like in strength and number, rate processes were deconvoluted from ne...

After undergoing a manufacturing process, materials may exhibit internal stresses referred to as residual stresses. In steel-composite hybrid structures, residual stresses are typically formed due to the unequal thermal behaviour of the steel and composite. Thus, knowledge of the residual stress state is important in the assessment of the external-internal loading in steel-composite hybrid stru...