Background: Boron neutron capture therapy (BNCT) is a binary modality based on the nuclear reaction 10B (n, α) lithium-7 (7Li) that has been used to treat variety of tumors, among these, cutaneous melanoma (CM). In previous boron biodistribution studies in agreement with personalized oncology, we have demonstrated boronophenylalanine (BPA) uptake can be correlated tumoral temperature and viabil...

Carborane-appended 5-thio-Dglucopyranose (TDG) and deoxyribose derivatives were synthesized and evaluated for accumulation in cancer cells, cytotoxicity, and efficacy in an in vitro boron neutron capture therapy (BNCT) assay. The nidocarborane-appended sugar conjugates were found to be less cytotoxic than their closo-carborane analogues. Biological evaluation with human hepatocellular carcinoma...

BACKGROUND Osteosarcoma is the most frequent primary malignant bone tumour, and its incidence is higher in children and adolescents, for whom it represents more than 10% of solid cancers. Despite the introduction of adjuvant and neo-adjuvant chemotherapy that markedly increased the success rate in the treatment, aggressive surgery is still needed and a considerable percentage of patients do not...

BACKGROUND Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when boron-10 is irradiated with low-energy thermal neutrons to yield high linear energy transfer alpha particles and recoiling lithium-7 nuclei. Clinical interest in BNCT has focused primarily on the treatment of high-grade gliomas and either cutaneous primaries or cerebral metastases of melanoma, most...

Introduction Electron linear accelerator (LINAC) can be used for neutron production in Boron Neutron Capture Therapy (BNCT). BNCT is an external radiotherapeutic method for the treatment of some cancers. In this study, Varian 2300 C/D LINAC was simulated as an electron accelerator-based photoneutron source to provide a suitable neutron flux for BNCT. Materials and Methods Photoneutron sources w...