Las uniones estrechas (UE) son estructuras altamente complejas que se localizan en la porcion mas apical de membrana basolateral y estan compuestas por una serie proteinas, como claudinas, ocludinas proteinas familia ZO. UE restringen el paso sustancias potencialmente daninas o microorganismos a lo largo del espacio paracelular, participan manera importante procesos mecanotransduccion senalizac...

Modulation of the blood coagulation fibrinolytic system is an essential function vascular endothelial cells. Tissue plasminogen activator (t-PA) and inhibitor-1 (PAI-1) are major regulatory proteins synthesized by cells; activity dependent on balance between these proteins. Previously, we have reported that cadmium, initiator ischemic heart disease, induces PAI-1 expression suppresses in cultur...