We discuss here a new approach to detecting hepatotoxicity by employing concentration changes of liver-specific blood proteins during disease progression. These proteins are capable of assessing the behaviors of their cognate liver biological networks for toxicity or disease perturbations. Blood biomarkers are highly desirable diagnostics as blood is easily accessible and baths virtually all or...

Heart attacks are a highly prevalent and often life-threatening disease in modern society. Numerous studies have now shown that many biomarkers blood been identified as markers for the detection of heart attack some widely used clinical practice, including protein-based nucleic acid-based markers. With further research into pathogenesis attacks, new, simpler earlier identified. In this paper, w...

genetic diversity of red jabal barez red goat population was studied based on eight microsatellite markers consist bm1312, maf64, ilsts034, ilsts059, orafcb20, il2ra, lscv24 and lscv11. blood sample extracted of 100 red jabal barez goats were randomly collected from 10 farms and dna was isolated using the diatom dna prep kit. the pcr reactions were successfully done and all loci showed suitable...

conclusions while the crp value was in patients with acute brucellosis in the current study, the mpv, rdw and leukocyte counts were within the normal range. crp value remains the most valuable inflammatory marker in cases of acute brucellosis. results the follow-up within the year after treatment was examined. the values of age, gender, leukocyte count, c-reactive protein, rdw and mpv were reco...

Background: the general lifespan has been prolonged greatly during past century, and incidence of age-associated diseases, including neurodegenerative ones, increased as well. However, modelling age-related pathologies is mostly conducted on adult rodents. We studied morphofunctional changes in brain peripheral blood Wistar rats comparison with old to determine physiological differences adaptiv...

Noninvasive markers of fibrosis have emerged as an alternative to the staging of fibrosis by means of liver biopsy. Apart from being noninvasive and thus lacking the adverse effects of liver biopsy, they offer some advantages such as reduced risk of sampling error, objectiveness in the interpretation of the result, appropriateness for repeated measurements and lower cost. Many studies have vali...

The analysis of whole blood samples by flow cytometry for pharmacodynamic and biomarker assessments in clinical studies has been limited by the necessity to test these samples within a short time frame after blood collection. In most clinical studies, blood specimens are shipped to a centralized testing facility; it is critical to demonstrate specimen stability over a period of time which will ...

BACKGROUND AND PURPOSE The absence of a widely available and sensitive diagnostic test for acute cerebral ischemia remains a significant limitation in the diagnosis and management of stroke. The objective of this study was to examine the feasibility of developing a diagnostic panel of blood-borne biochemical markers of cerebral ischemia. METHODS Serial blood samples were obtained from patient...

Peripheral blood T-cell responses are used as biomarkers in hepatitis C virus (HCV) vaccine trials. However, it is not clear how T-cell responses in the blood correlate with those in the liver, the infection site. By studying serial liver and blood samples of five vaccinated and five mock-vaccinated control chimpanzees during acute HCV infection, we demonstrate a correlation between HCV-specifi...