We analyzed brain tissue in 139 rats for adenosine and its metabolites, inosine and hypoxanthine, during the initial 120 seconds of seizures induced by bicuculline. We also measured ATP, ADP, AMP, phosphocreatine (PCr), and lactate. We divided the rats into four groups by adjustment of their preictal arterial oxygen tension: group I, PaO2 > 200 mm Hg; group II PaO2 = 50 mm Hg; and group III: Pa...

objective: the aim of this study was to evaluate the effect of premenstrual syndrome (pms) treatment with selective serotonin reuptake inhibitor (ssri) on treatment response of refractory hypertension of the patients. method: this was a triple-blind randomized clinical trial conducted on female patients suffering from refractory hypertension and pms at the same time. we obtained informed consen...

The purpose of this experiment was to determine the effect of long-term low-dose administration of mercury (Hg) on thyroid function in sheep. In this experiment, 10 clinically healthy, adult, male Iranian sheep, aged approximately 1 year, were randomly allocated into the control (n=5) and mercury (Hg-)-treated (n=5) groups. Both groups were kept under identical conditions in terms of food and e...

Background and Purpose—Trial data suggest that dipyridamole, with or without aspirin, is more efficacious in the secondary prevention of stroke than of coronary events. This selective effect might be attributed to blood pressure lowering by dipyridamole. Therefore, we aimed to assess the effect on blood pressure in the setting of a randomized clinical trial in patients with cerebral ischemia of...

OBJECTIVE To determine the effects of dietary patterns on blood pressure in subgroups. METHODS Dietary Approaches to Stop Hypertension (DASH) was a randomized controlled feeding study conducted at 4 academic medical centers. Participants were 459 adults with untreated systolic blood pressure less than 160 mm Hg and diastolic blood pressure 80 to 95 mm Hg. For 3 weeks, participants were fed a ...

OBJECTIVES To examine the changes in blood pressure over time in a cohort of young adults attending university between 1948 and 1968. DESIGN Cross sectional study. SETTING Glasgow University. PARTICIPANTS 12 414 students aged 16-25 years-9248 men (mean age 19.9 years) and 3164 women (19.2 years)-who participated in health screening on entering university between 1948 and 1968. MAIN OUTC...

Activation of the sympathetic nervous system contributes to the pathogenesis of obesity-induced hypertension. The present study sought to determine whether sympathetic regulatory neurons of the rostral ventrolateral medulla contribute to the elevated blood pressure in obese rats. Male Sprague-Dawley rats (350 to 425 g) were placed on a moderately high-fat diet (32% kcal as fat) or a low-fat (LF...

background during laparoscopy, insufflation of an inert gas in the peritoneal cavity creates a working space to facilitate surgery. the space should be large enough to facilitate surgery without increasing intra-abdominal pressure (iap) over a threshold limit (usually 15 mm hg). objectives this experimental study was performed to evaluate the effects of increasing in intra-abdominal pressure on...

AIM To investigate the relation between change in systemic blood pressures and change in intraocular pressure. METHODS This was a population based study of people 43-86 years old living in Beaver Dam, Wisconsin. Measurements at baseline (1988-90) and 5 year follow up of systemic blood pressures, intraocular pressures, and history of use of blood pressure medications. RESULTS Intraocular pre...

Background—Breast-feeding in infancy has been associated with decreased coronary heart disease mortality, but the underlying mechanisms are unclear. We investigated the association of breast-feeding with blood pressure in a contemporary cohort. Methods and Results—In a prospective cohort study (ALSPAC, United Kingdom), a total of 7276 singleton, term infants born in 1991 and 1992 were examined ...