R DECADES, knowledge about blood group antigens I? has constituted the basis for sound transfusion practice. Although blood group serology may seem a research area largely restricted to the surface antigens on human red blood cells (and platelets), many of the known blood group antigens have a far broader tissue expression than generally acknowledged. The AB0 blood group system, discovered in 1...

R DECADES, knowledge about blood group antigens I? has constituted the basis for sound transfusion practice. Although blood group serology may seem a research area largely restricted to the surface antigens on human red blood cells (and platelets), many of the known blood group antigens have a far broader tissue expression than generally acknowledged. The AB0 blood group system, discovered in 1...

There are 284 blood group antigens recognized by the ISBT Committee on Terminology for Red Cell Surface Antigens. Of these, 244 antigens are included in one of 29 blood groups systems. The rest are included in collections of similar antigens, or in a series of either low incidence or high incidence antigens. The biochemical work of the middle of the last century revealed these antigens to be ca...

Background: Glycophorin A (GPA) is one of two glycoproteins found on the surface human red blood cells (RBCs) that constitute MNS group system. The structure GPA’s extracellular domain unknown despite previous attempts using X-ray crystallography and NMR spectroscopy. As a result, there knowledge gap regarding antigen presentation. This hinders production monoclonal antibodies (mAbs) against an...

BACKGROUND Molecular testing is more precise compared to serology and has been widely used in genotyping blood group antigens. Single nucleotide polymorphisms (SNPs) of blood group antigens can be determined by the polymerase chain reaction with sequence specific priming (PCR-SSP) assay. Commercial high-throughput platforms can be expensive and are not approved in China. The genotype frequencie...

ABO histo-blood group antigens have been postulated to modify pathogen spread through the action of natural antibodies and complement. The antigens are generated by a polymorphic glycosyltransferase encoded by 2 dominant active and a recessive inactive allele. In this study we investigated whether ABO sugars are incorporated into the envelope of HIV-1 virions. HIV vectors derived from cells exp...

results there were 64 women and 936 men in the population under study. the mean ± sd age of the donors was 38 ± 11 years. 80 out of 1000 samples (8%) were found to be positive for hbcab. hbv dna was detected in 50% of hbcab positive specimens. the mean ± sd age of donors without hbv dna was 37.7 ± 10.5 years and for donors with hbv dna was 40.9 ± 11.2 years (p = 0.05). objectives the aim of thi...

he ABH antigens are histo-blood group antigens that are resent in circulating blood cells, tissues and body fluids. he association of blood groups with various disease states as been well documented in the literature. Both hematopoitic and non-hematopoietic malignancies are associated with lood group changes. In solid organ malignancies, excessive lood group substances produced by the tumor lea...

Erythrocytes (E) lacking high incidence blood group antigens were screened by an antiglobulin test with a monoclonal antibody to human complement receptor type 1 (CR1; C3b/C4b receptor; CD35). Some examples of E lacking Knops, McCoy, Swain-Langley, and York antigens, a serologically related group, were not agglutinated. Moreover, E of the null phenotype for these same antigens were nonreactive....