PURPOSE OF REVIEW To review the evidence that the Alzheimer peptide β-amyloid interacts with the blood coagulation system and influences the pathophysiology of the disease. RECENT FINDINGS β-amyloid can interact with fibrinogen and blood coagulation factor XII and trigger ischemia and inflammation. SUMMARY β-amyloid interacts with fibrinogen and factor XII. These interactions can lead to in...

In terms of its soluble precursors, the coagulation proteome varies quantitatively among apparently healthy individuals. The significance of this variability remains obscure, in part because it is the backdrop against which the hemostatic consequences of more dramatic composition differences are studied. In this study we have defined the consequences of normal range variation of components of t...

The relationship between blood coagulation factors and the promotion or inhibition of the antiinflammatory response continues to be defined through basic research. The potential key role of blood coagulation factors in the response during sepsis provides an exciting potential mechanism(s) for modification through the application of new therapies. The complexity of the potential multiple actions...

Mitchell J. Cohen discusses why trauma care must go beyond restoring perfusion to target disorders of inflammation and coagulation in severely injured patients.

The effect of antibiotics on the blood coagulation mechanism has attracted the attention of many workers in various countries. Investigations have mostly been based on changes in the clotting time before, during, and after administration of the drugs in vivo (Parker and Wright, 1952; Galt and Hunter, 1950; Miller and Bass, 1952; Casassa, 1952; Macht, 1952; and many others). This approach has le...

Clinical and experimental observations are described that indicate that intra-articular fibrinogenolysis is a cause of the defect of coagulation seen when blood is extravasated into a synovial joint.