Post hoc analyses from the B-type natriuretic peptide for Acute Shortness of Breath Evaluation (BASEL)-II-ICU study suggest an association between beta-blocker usage at admission and improved mortality in patients treated in the intensive care unit for acute respiratory failure. Although this evidence is encouraging, there is a need for a phase 2 proof-of-concept randomized controlled trial of ...

UNLABELLED Because of the difficulty of predicting the response of patients with idiopathic dilated cardiomyopathy (IDC) to beta-blocker therapy, this study was performed to evaluate whether gated myocardial SPECT (gated SPECT) could be useful for predicting that response. METHODS We performed gated SPECT with (99m)Tc-sestamibi on 38 patients with IDC before treatment with a beta-blocker and ...

INTRODUCTION AND OBJECTIVES A significant percentage of patients selected as candidates for heart transplantation can be stabilized by medical treatment, thereby enabling indefinite postponement of inclusion on the operation list. The aim of this study was to investigate the prognosis of these patients. PATIENTS AND METHOD We studied retrospectively 118 patients with severe left ventricular s...

Acute bleeding from esophageal varices is a medical emergency. It requires a structured therapeutic strategy which is adapted to the local resources. The primary goal is to stop bleeding, preferably by endoscopic sclerotherapy or ligation. In situations where endoscopic intervention is not possible as a first-line treatment, therapy with balloon tamponade or vasoactive drugs (terlipressin or oc...

OBJECTIVE: To describe the epidemiology, impact, pathogenesis, patient presentation, and treatment of stable angina, including the use of vasculoprotective and antianginal drug therapies and coronary revascularization procedures. SUMMARY: Stable angina is an age-related condition that typically affects men at an earlier age than women, adversely affects quality of life, and increases mortality....

BackgroundFoundational quadruple therapy (RAAS inhibition, Beta-blocker, MRA, SGLT2i) for the management of heart failure reduced ejection fraction (HFrEF) confers significant benefit in terms mortality and (HF) hospitalization. This approach received a strong recommendation CCS/CHFS Heart Failure Guidelines. Recent data indicates that SGLT2i also reduce risk HF hospitalization preserved (HFpEF...

Prostate cancer has been the most common malignant tumor in men Poland since 2016 and is second cause of death this group patients. The basic method treatment patients with advanced prostate androgen deprivation therapy, however, over time, evolves into a castration-resistant form, which poses significant threat to patient's life. This article presents case an elderly patient internal diseases,...

Background—Few data exist regarding contemporary care patterns for heart failure (HF) in the outpatient setting. IMPROVE HF is a prospective cohort study designed to characterize current management of patients with chronic HF and ejection fraction 35% in a national registry of 167 US outpatient cardiology practices. Methods and Results—Baseline patient characteristics and data on care of 15 381...

PURPOSE Congestive heart failure is an important cause of patient morbidity and mortality. Although several randomized clinical trials have compared beta-blockers with placebo for treatment of congestive heart failure, a meta-analysis quantifying the effect on mortality and morbidity has not been performed recently. DATA SOURCES The MEDLINE, Cochrane, and Web of Science electronic databases w...

OBJECTIVES We sought to examine associations between initiation of beta-blocker therapy and outcomes among elderly patients hospitalized for heart failure. BACKGROUND Beta-blockers are guideline-recommended therapy for heart failure, but their clinical effectiveness is not well understood, especially in elderly patients. METHODS We merged Medicare claims data with OPTIMIZE-HF (Organized Pro...