C,N-coupling reactions of aryl chlorides and aryl amines catalyzed by a nickel catalyst are reported. 17 new amines are synthesized in yields of 57-99%. 2,6-Dichloro substituted imines can be selectively aminated. Both mono- and di-aminated products are obtained. Different substrates and amines are tested to look into the influence of electronic effects and steric hindrance to the reaction. An ...

The rhodium-catalyzed regioselective amination of tertiary allylic trichloroacetimidates with unactivated aromatic amines is a direct and efficient approach to the preparation of α,α-disubstituted allylic aryl amines in good yield and with excellent regioselectivity. This method is applicable to a variety of unactivated primary and secondary amines and allows for the preparation of reverse pren...

109 Biogenic amines are a group of organic nitrogenous compounds formed and degraded by the metabolisms of living organisms (microorganisms, plants and animals). The main biogenic amines associated with wine are putrescine, histamine, tyramine and cadaverine, followed by phenylethylamine, spermidine, spermine, agmatine and tryptamine. Biogenic amines in wine can be formed by various microorgani...

blended with face-to-face treatment: Results from a naturalistic study. Internet Interventions, Abstract Objective Research has convincingly demonstrated that Internet interventions are effective for anxiety and depression and it is suggested that these interventions can reduce therapist time and thus save costs. Therefore, many Dutch mental health organizations have started to implement these ...

Aromatic amines are important intermediates in industrial manufacturing. N-Oxidation to N-hydroxyarylamines is a key step in determining the genotoxic properties of aromatic amines. N-Hydroxyarylamines can form adducts with DNA, with tissue proteins, and with the blood proteins albumin and hemoglobin in a dose-dependent manner. The determination of hemoglobin adducts is a useful tool for biomon...

Trace amines, including tyramine and beta-phenylethylamine (beta-PEA), are constituents of many foods including chocolate, cheeses and wines and are generated by so-called 'friendly' bacteria such as Lactobacillus, Lactococcus and Enterococcus species, which are found in probiotics. We therefore examined whether these dietary amines could exert pharmacological effects on the gut and its vascula...

The sulfated polyborate catalyzed an efficient and chemoselective N-tert-butyloxycarbonylation of amines under ultrasonic irradiation is developed. A broad substrate scope has been demonstrated for N-Boc protection various primary/secondary amines. It allows converting several aliphatic/aryl/heteroaryl amines, amino alcohol, aminoester, chiral to their N-Boc-protected derivatives solvent-free c...

BACKGROUND Many studies have provided evidence for the effectiveness of Internet-based stand-alone interventions for mental disorders. A newer form of intervention combines the strengths of face-to-face (f2f) and Internet approaches (blended interventions). OBJECTIVE The aim of this review was to provide an overview of (1) the different formats of blended treatments for adults, (2) the stage ...

OBJECTIVE To evaluate the clinical and cost-effectiveness of a new blended dental contract incentivising improved oral health compared with a traditional dental contract based on units of dental activity (UDAs). DESIGN Non-randomised controlled study. SETTING Six UK primary care dental practices, three working under a new blended dental contract; three matched practices under a traditional ...

BACKGROUND There is need for more cost and time effective treatments for depression. This is the first randomised controlled trial in which a blended treatment--including four face-to-face sessions and a smartphone application--was compared against a full behavioural treatment. Hence, the aim of the current paper was to examine whether a blended smartphone treatment was non-inferior to a full b...