Dear Editor We report an unusual case of myeloperoxidase (MPO)-positive acute megakaryoblastic leukemia (AMKL). The patient was a 63-yr-old woman referred to our hospital with anemia and dyspnea. General physical examination revealed no lymphadenopathy or hepatosplenomegaly. An initial complete blood count indicated white blood cell counts of 26.78×10/L, including 47% blasts, hemoglobin of 7.2 ...

A 15-year-old boy presented at our center with shortness of breath and swelling in the neck since 4 months. On examination he had hepatosplenomegaly and generalized lymphadenopathy. Clinically, acute lymphoblastic leukemia, possibly T-cell lineage was considered. His hemogram showed a hemoglobin level of 56 gm/L, total leukocyte count of 3.4 10/L, platelets of 105 10/L, and 50% circulating blas...

background: acute myeloid leukemia (aml) with translocation (3,3) is a form of aml that may present de novo or may arise from a previous myelodysplastic syndrome. it is often associated with normal or elevated peripheral blood platelet count and increased bone marrow megakaryocytes with associated multi lineage dysplasia. a subset of patients present with hepatosplenomegaly while a few cases ha...

Background: Automatic Cell Counter devises make the CBC differential very easy and delivering the results in few second. However, the problem with this device is facing a flag requires a time-consuming microscopic review of the specimen which causes unacceptable wait times for patient as well as costs for laboratories. In this study, we calculated the validity of WBC d...

Clinics Splenomegaly; chronic phase (lasts about 3 yrs) with maintained cell’s normal activities, followed by accelerated phase(s)(blasts still < 15%), and blast crisis (BC-CML) with blast cells > 30%; blood data: WBC: 100 X 10/l and more during chronic phase, with basophilia; a few blasts; thrombocytosis may be present; low leucocyte alkaline phosphatases; typical acute leukaemia (AL) blood da...

Dear Editor, Determination of the percentage of blasts in the bone marrow (BM) is one of the critical factors in diagnosing MDS. Flow cytometry (FCM) of BM cells has been introduced as an important co-criterion for diagnosing MDS [1-3]. However, FCM has not been well accepted because of the lack of consensus of the criteria to define a phenotypic myeloblast and the appropriate denominator for c...

DOI: 10.1590/S1679-45082016AI3516 Acute myeloid leukemia (AML) results from accumulation of abnormal blasts in the bone marrow, interfering with hematopoiesis.(1) Multiparametric flow cytometry is an important and well-known tool for AML diagnosis and for monitoring of minimal residual disease.(2) However, this technique is still poorly explored to elucidate clonal evolution of the leukemia. We...