BACKGROUND The focus of the diagnostic process in chest pain patients at the emergency department is to identify both low and high risk patients for an acute coronary syndrome (ACS). The HEART score was designed to facilitate this process. This study is a prospective validation of the HEART score. METHODS A total of 2440 unselected patients presented with chest pain at the cardiac emergency d...

BACKGROUND Diabetes mellitus is associated with increased cardiovascular (CV) morbidity and mortality and with greater ECG left ventricular hypertrophy (LVH); however, it is unclear whether diabetes attenuates regression of hypertensive LVH and whether regression of ECG LVH has similar prognostic value in diabetic and nondiabetic hypertensive individuals. METHODS AND RESULTS A total of 9193 h...

Address all correspondence and request for reprints to: Jan Dommerholt Bethesda Physiocare, Inc. 7830 Old Georgetown Road, Suite C-15 Bethesda, MD 20814-2440 [email protected] Abstract: This article provides a best evidence-informed review of the current scientific understanding of myofascial trigger points with regard to their etiology, pathophysiology, and clinical implication...

In Cambodia, micronutrient deficiencies remain a critical public health problem. Our objective was to evaluate the impact of multi-micronutrient fortified rice (MMFR) formulations, distributed through a World Food Program school-meals program (WFP-SMP), on the hemoglobin concentrations and iron and vitamin A (VA) status of Cambodian schoolchildren. The FORISCA-UltraRice+NutriRice study was a do...

(1) Part 3 of a series on pheromone synthesis. For part 2 see P. J. Kocienski and G. J. Cernigliaro, J. Org. Cbem., 41, 2927 (1976). (2) H. M. Fales, M. S. Blum, R. M. Crewe, and J. M. Brand, J. lflsect Pbysiol., 18, 1077 (1972). (3) J. A. Katzeneilenbogen and T. Utawanit, J. Am. Cbem. Soc., 96, 6153 (1974). (4) L. A. Carpino, J. Am. Cbem. SOC., 80,601 (1958); L. A. Carpino, P. H. Terry, and S....

We present Keck/DEIMOS spectroscopy of Segue 1, an ultra–low-luminosity ( MV = −1.5+0.6 −0.8 ) Milky Way satellite companion. While the combined size and luminosity of Segue 1 are consistent with either a globular cluster or a dwarf galaxy, we present spectroscopic evidence that this object is a dark matter-dominated dwarf galaxy. We identify 24 stars as members of Segue 1 with a mean heliocent...

Background and Purpose—Hypertension is a major risk factor for ischemic and hemorrhagic stroke and may also cause more chronic and subtle brain injury. Progressive brain changes in a rat model of renal hypertension have been assessed to better understand the pathogenesis of hypertensive brain damage. Methods—Young adult rats were made hypertensive by partial occlusion of both renal arteries. MR...

Despite the importance of hemodialysis vascular access, the cost of vascular access care has not been studied in detail. A prospective cost analysis was performed among incident hemodialysis patients to determine the cost of vascular access care overall and on the basis of access type. Detailed clinical and demographic information, as well as data on access type, was collected for all local inc...

Hepatitis C virus (HCV) and human pegivirus (HPgV), formerly GBV-C, are the only known human viruses in the Hepacivirus and Pegivirus genera, respectively, of the family Flaviviridae. We present the discovery of a second pegivirus, provisionally designated human pegivirus 2 (HPgV-2), by next-generation sequencing of plasma from an HCV-infected patient with multiple bloodborne exposures who died...

BACKGROUND Non-Hodgkin lymphoma (NHL), the most common hematologic malignancy, consists of numerous subtypes. The etiology of NHL is incompletely understood, and increasing evidence suggests that risk factors may vary by NHL subtype. However, small numbers of cases have made investigation of subtype-specific risks challenging. The International Lymphoma Epidemiology Consortium therefore underto...