UNLABELLED We investigated the effect of epidural local anesthetic blockade on urinary substance P levels in five patients suffering from painful flare-ups of interstitial cystitis. Urine was collected in 24-h intervals commencing at the onset of an epidural bolus of 0.25% bupivacaine followed by maintenance epidural infusions of 0.05% bupivacaine. Substance P was measured by radioimmunoassay. ...

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease the Genitourinary Tract: Interstitial Cystitis (PD01)1 Sep 2021PD01-10 SMALL FIBER POLYNEUROPATHY: A NEXUS LINKING CO-OCCURRING PAIN SYNDROMES IN WOMEN WITH INTERSTITIAL CYSTITIS/BLADDER SYNDROME? Raymond Xu, Tyler Overholt, Catherine A. Matthews, Robert Evans, Gopal Badlani, Christine Ahn, Trang Simon, and Stephen J. Walke...

CYCLOPHOSPHAMIDE-INDUCED CYSTITIS REDUCES ASIC CHANNEL, BUT 1 ENHANCES TRPV1 RECEPTOR FUNCTION IN RAT BLADDER SENSORY NEURONS 2 3 Khoa Dang Klaus Bielefeldt and G.F. Gebhart 4 Departments of Pharmacology and Medicine, Carver College of Medicine, The 5 University of Iowa, Iowa City, IA 52242 6 7 8 Running title: Cystitis reduces ASIC but increases TRPV1 function 9 10 11 Author for correspondence...

Regulation of the VEGF-VEGF receptor system was examined in the urinary bladder after acute (2-48 h) and chronic (10 days) cyclophosphamide (CYP)-induced cystitis. ELISAs demonstrated significant (P < or = 0.01) upregulation of VEGF in whole urinary bladder with acute and chronic CYP-induced cystitis; however, the magnitude of increase was greater after acute (2-4 h) cystitis. Immunohistochemis...

Painful bladder syndrome/interstitial cystitis (PBS/IC) encompasses a major portion of the “painful bladder” disease complex. “Painful bladder disorders” comprise a large group of patients with bladder and/or urethral and/or pelvic pain, irritative voiding symptoms (urgency, frequency, nocturia, and dysuria), and sterile urine cultures. Painful bladder conditions with well-established causes in...

TO THE EDITOR: Ketamine-induced cystitis was first reported by Shahani et al. in 2007 (6). Clinical presentations of this entity is characterized by lower urinary tract symptoms (LUTS), such as frequency, urgency, gross hematuria, and bladder pain (2, 6). The underlying mechanisms are still unelucidated in ketamine-induced cystitis, and the approaches to therapy include cessation of ketamine, m...