BACKGROUND An umbilical metastatic lesion is called 'Sister Mary Joseph's nodule'. It is an uncommon clinical or radiographic finding, and it is rare as the first sign of a malignant disease. CASE PRESENTATION We report three cases of Sister Mary Joseph's nodule. In the three cases presented, the primary tumor was an adenocarcinona of the sigmoid colon, a carcinoma of the bladder, and an aden...

Primary gastric chorioadenocarcinoma (PGC) is a rare and rapidly invasive tumor. Choriocarcinoma is usually known to be of endometrial origin and gestational; however, it has been reported in other extragenital organs, such as the gall bladder, prostate, lung, liver, and the gastrointestinal tract. Human chorionic gonadotropin related neoplasms of the stomach are seldom discussed in the literat...

as a tumor composed of admixed benign epithelial and malignant nonepithelial components, and this tumor usually develops as a solitary lesion in the uterine corpus (1). These neoplasms can develop in the endometrial tissue as well as in the ectopic foci of endometriosis. Rare extrauterine müllerian adenosarcomas have been reported to arise in the ovary, cervix, vagina, pelvis, bladder and colon...

Retroperitoneal benign lipomas are extremely rare and represent about 2.9% of all primary retroperitoneal tumors. About 80% of the tumors in the retroperitoneal cavities are malignant neoplasms. We experienced a case of a retroperitoneal lipoma simulating an ovarian mature cystic teratoma. A diagnosis was correctly made by magnetic resonance imaging (MRI) prior to surgery, and a total tumorecto...

Gastrointestinal stromal tumors (GISTs) compose the largest category of well-recognized nonepithelial neoplasms of the gastrointestinal tract (GI). GISTs of the gallbladder are extremely rare tumors. Only four malignant, two benign and one GIST-like tumor of the gall bladder have ever been described. The four malignant GISTs were all positive for CD 117 antigen (c-kit). We present for the first...

OBJECTIVES We have synthesized the principal advances in the field of the study of epigenetics and specifically DNA methylation regarding the diagnosis of urological neoplasms. ACQUISITION OF EVIDENCE Review of the literature (PubMed, MEDLINE and Cochrane) on the study of DNA methylation in urological neoplasms (prostate cancer, bladder cancer, renal cancer and testicular cancer), considering...

Introduction. Simultaneous ipsilateral coexistence of renal cell carcinoma (RCC) and upper urinary tract urothelial (UTUC) rarely occurs. Balkan endemic nephropathy (BEN) is a chronic degenerative tubulointerstitial disease, strongly associated with UTUC. Case outline. ? 60-year-old man from the region BEN was referred to our clinic due right flank pain, fever, purulent discharge cutaneous fist...

STUDY OBJECTIVE The aim was to investigate the relationship between socioeconomic status and cancer survival. DESIGN This was a prospective study, linking census and vital registration records for an approximate 1% representative sample of those enumerated in England and Wales in the 1971 census. SETTING The study population is nationwide. PARTICIPANTS The study sample consists of 250,588...

Groups of 50 female Swiss mice were fed for 18 months on a standard diet containing sucrose (10 %), sodium cyclamate (5 %) or saccharin (5 %), while 100 control mice were fed on the standard diet alone. The survival times were comparable in all groups and no acute toxic effects were encountered. No local tumours in the gastro-intestinal tract, nor excess incidence of distant tumours, were found...

We encountered an undescribed histologic feature of papillary urothelial neoplasms: "urothelial eddy", which was histologically reminiscent of squamous eddy of irritated follicular keratosis of the skin. A review of 756 patients with transurethral resection of bladder tumor revealed 10 patients (1.3%) of papillary urothelial neoplasms with urothelial eddies. All cases were male with a median ag...