ID: 13564 Title: A novel conformal arc technique for postoperative whole pelvic radiotherapy of endometrial cancer Introduction: Conventional whole pelvic radiotherapy (WPRT) with three-dimensional conformal radiotherapy (3D-CRT) exposes most of the contents of the true pelvis to the prescribed dose. Intensity-modulated radiation therapy (IMRT) provides more conformal dose distribution and bett...

Three dimensional planning for high-dose-rate (HDR) brachytherapy in cervical cancer has been highly recommended by consensus guidelines such as the American Brachytherapy Society (ABS) and the Groupe Européen de Curiethérapie - European Society for Radiotherapy and Oncology (GEC-ESTRO). In this document, we describe our experience with computed tomography (CT)-based planning using the tandem/r...

PURPOSE The contrast in dose distribution between proton radiotherapy (RT) and intensity-modulated RT (IMRT) is unclear, particularly in regard to critical structures such as the rectum and bladder. METHODS AND MATERIALS Between August and November 2006, the first 10 consecutive patients treated in our Phase II low-risk prostate proton protocol (University of Florida Proton Therapy Institute ...

PURPOSE Locally recurring cervical cancer after surgery and adjuvant radiotherapy remains a major therapeutic challenge. This paper presents a new therapeutic technique for such patients: interstitial brachytherapy (BT) guided by real-time three-dimensional (3D) computed tomography (CT). MATERIAL AND METHODS Sixteen patients with recurrent cervical cancer after radical surgery and adjuvant ex...

Introduction: Beam-angle optimization (BAO) is a computationally intensive problem for a number of reasons. First, the search space of the solutions is huge, requiring enumeration of all possible beam orientation combinations. For example, when choosing 4 angles out of 36 candidate beam angles, C36 = 58905 possible combinations exist.  Second, any change in a   beam 4 config...

ADAPTIVE RADIATION THERAPY OF PROSTATE CANCER by NING WEN August 2010 Advisor: Dr. Teamour Nurushev Major: Medical Physics Degree: Doctor of Philosophy ART is a close-loop feedback algorithm which evaluates the organ deformation and motion right before the treatment and takes into account dose delivery variation daily to compensate for the difference between planned and delivered dose. It also ...

PURPOSE To demonstrate the feasibility of using a knowledge base of prior treatment plans to generate new prostate intensity modulated radiation therapy (IMRT) plans. Each new case would be matched against others in the knowledge base. Once the best match is identified, that clinically approved plan is used to generate the new plan. METHODS A database of 100 prostate IMRT treatment plans was ...

BACKGROUND Intrathecal administration of opioids may cause lower urinary tract dysfunction. In this study, the authors compared the effects of morphine and sufentanil administered intrathecally in a randomized double-blind fashion (two doses each) on lower urinary tract function in healthy male volunteers. METHODS Urodynamic evaluation was performed before and every hour after drug administra...

Abstract Purpose The aim of this study is to quantify the potential benefits a flattening filter‐free (FFF) beam and implement dose‐computation algorithm for cervical radiotherapy through dosimetric radiobiological analyses using RapidArc. Methods Thirty‐three patients were enrolled, four RapidArc plans created each patient dual‐arc filter 6‐MV FFF photon beams two calculation algorithms. Homog...

This study aimed to evaluate the performance of the hybrid deformable image registration (DIR) method in comparison with intensity-based DIR for pelvic cone-beam computed tomography (CBCT) images, using intensity and anatomical information. Ten prostate cancer patients treated with intensity-modulated radiation therapy (IMRT) were studied. Nine or ten CBCT scans were performed for each patient....