The Polyomaviridae family includes ubiquitous viruses with specific host spectra. Human polyomavirus BK (BKV) was discovered in 1971 and shortly after that became evident that around 80% of adults had anti-BKV antibodies. This raised important questions connected with its mode of transmission and pathogenesis. Nowadays they are still unclear (Sessa, 2008). Following primary infection, which is ...

BK virus (BKV) is a common opportunistic pathogen in kidney transplant recipients and one of the most challenging causes allograft dysfunction loss. Although over-immunosuppression remains primary risk factor for BKV infection after transplantation, male gender, older recipient age, prior rejection episodes, degree human leukocyte antigen mismatching, prolonged cold ischemia time, serostatus ur...

BK virus (BKV) pneumonia is a rare entity especially seen in immunosuppressed patients, for which cidofovir the used treatment option. We describe case of young female patient who presented altered kidney function six months following transplantation focal segmental glomerulosclerosis and was found to have BKV nephritis. Her in-hospital stay complicated by requiring mechanical ventilation, addi...

BK virus (BKV) is a non-enveloped DNA virus of the polyomaviridae family that causes an interstitial nephritis in immunosuppressed patients. BKV nephropathy is now a leading cause of chronic kidney disease and early allograft failure following kidney transplantation. It is also known to cause renal disease with a progressive decline in kidney function in non-renal solid organ transplant (NRSOT)...

We report a case of a 64-year-old woman who underwent left adrenalectomy with removal of a 8,5 cm clinically non-functioning adrenocortical adenoma and a 4-cm myelolipoma. Molecular testing for viral infection demonstrated the presence of cytomegalovirus (CMV) DNA sequences in the adrenal adenoma, but not in the myelolipoma (confirmed by immunohistochemistry). Moreover, the adrenal adenoma was ...

AIM To evaluate incidence, risk factors and treatment outcome of BK polyomavirus nephropathy (BKVN) in a cohort of renal transplant recipients in the Auckland region without a formal BK polyomavirus (BKV) surveillance programme. METHODS A cohort of 226 patients who received their renal transplants from 2006 to 2012 was retrospectively reviewed. RESULTS Seventy-six recipients (33.6%) had a B...

This study evaluate the potential of plasmatic CXCL-10 (pCXCL-10) as a pre&post transplantation prognostic and diagnostic biomarker T-cell-mediated rejection (TCMR), antibody-mediated (ABMR) subclinical (SCR) risk in adult kidney recipients considering BKV CMV infections possible clinical confounder factors. Twenty-eight 100 patients included experienced (TCMR:14; ABMR:14); 8 SCR; 13 16 were di...

Nephropathy caused by poliomavirus (BKVAN) in transplant recipients is responsible for the loss of the transplanted organ. In this study we suggest a non-invasive diagnostic protocol for the early identification of BKVAN during follow-up treatments. In 117 kidney transplant recipients follow-up was performed every three months during a two year period after transplantation and a positive screen...

Most research providing evidence for the role of oncogenic viruses in head and neck squamous cell carcinoma (SCC) development is focused on one type of virus without analyzing possible interactions between two or more types of viruses. The aim of this study was to analyse the prevalence of co-infection with human papillomavirus (HPV), Epstein-Barr virus (EBV) and polyoma BK virus (BKPyV) in ora...