BACKGROUND Endocrine-disrupting chemicals (EDCs) influence the activity of estrogen receptors (ERs) and alter the function of the endocrine system. However, the diversity of EDC effects and mechanisms of action are poorly understood. OBJECTIVES We examined the agonistic activity of EDCs through ERα and ERβ. We also investigated the effects of EDCs on ER-mediated target genes. METHODS HepG2 ...

The chemical upcycling of poly(bisphenol A carbonate) was carried out through organocatalysis using α-hydroxyketones as nucleophiles, leading to valuable vinylene carbonates.

STUDY QUESTION Are bisphenol A (BPA) and BPA analogs (BPA-A) safe for male human reproductive function? SUMMARY ANSWER The endocrine function of human testes explants [assessed by measuring testosterone and insulin-like factor 3 (INSL3)] was impacted by exposure of the human adult testis explants to BPA/BPA-A. WHAT IS KNOWN ALREADY The few epidemiologic studies performed suggest that bisphe...

Environmental exposures during sensitive windows of development can reprogram normal physiologic responses and alter disease susceptibility later in life in a process known as developmental reprogramming. For example, exposure to the xenoestrogen diethylstilbestrol during reproductive tract development can reprogram estrogen-responsive gene expression in the myometrium, resulting in hyperrespon...

Bisphenol A, a monomer of polycarbonate plastics and epoxy resins, is found in food packaging, can-coating chemicals and in dental sealants. Bisphenol A is released from polycarbonate flasks during autoclaving or from lacquer coatings in food cans, showing estrogenicity for human breast cancer MCF-7 cells (1, 2). This compound may be released into food, reach circulating blood and can cause gen...

BACKGROUND Maternal urinary biomarkers are often used to assess fetal exposure to phenols and their precursors. Their effectiveness as a measure of exposure in epidemiological studies depends on their variability during pregnancy and their ability to accurately predict fetal exposure. OBJECTIVES We assessed the relationship between urinary and amniotic fluid concentrations of nine environment...

Abstract Background Bisphenol A (BPA) causes environmental pollution and is used as a natural antioxidant to protect against chemical side-effects. Costus well-known medicinal plant containing several biologically active compounds. We investigated the protective effects of costus extract toxic BPA in rat testes. Results Biochemical immunohistochemical investigations revealed that bisphenol redu...