BACKGROUND The Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health (NIH) organized a workshop held in November 2011 to address knowledge gaps that limit the availability of adequate pediatric formulations. This workshop was used as a means to identify the types of research innovations needed and to stimulate research efforts desig...

Purpose: Many health systems are considered ill-equipped to adequately meet future demand. Although academic entrepreneurs and small medium-sized enterprises (SMEs) drive technology innovation, they often suboptimally consider important market stakeholder requirements. This can result in missed opportunities improve system performance, address demand-supply gaps, achieve financial rewards. Mark...

Docetaxel (Taxotere®) is a taxoid antineoplastic agent used in the treatment of various cancers. belongs to class IV drugs Biopharmaceutics Classification System (BCS), and their clinical use limited due extreme hydrophobicity, low water solubility, bioavailability, high toxicity. This study aims prepare nanoparticles for pulmonary delivery with enhanced solubility dissolution targeting tissues...

A high throughput encapsulation technique termed as electrospraying assisted by pressurized gas technology (EAPG) was used to produce nano-within-micro structures of a Biopharmaceutics Classification System (BCS) Class II model drug. Carvedilol is lipid soluble compound, poorly absorbed in the gastrointestinal tract. The produced formulations were characterized terms morphology, crystallinity, ...

Miconazole is a Biopharmaceutics Classification System (BCS) class II drug, thus limiting its oral bioavailability. Nanosponges can improve the bioavailability of poorly soluble drugs and sustain their release. The work was aimed at formulating miconazole nanosponges to enhance solubility consequently, Batches incorporating different concentrations (1, 2 3 %) nitrate were formed using ethyl cel...