Intracranial aneurysms (IA) are dilations of the cerebral arteries and, in most cases, have no symptoms. However, it is a very serious pathology, with high mortality rate after rupture. Several studies been focused only on hemodynamics flow within IA. besides effect flow, development and rupture IA also associated combination other factors such as wall mechanical behavior. Thus, objective this ...

Objective: Growth / Differentiation Factor-5 (GDF-5) is a member of the family of Bone Morphogenetic Proteins (BMPs) known to have diverse effects on musculoskeletal connective tissues [1,2]. Recently, biomechanical and ultrastructural abnormalities have been demonstrated in several collagen-rich tissues from GDF-5 deficient mice, including Achilles tendon, tail tendon, and long bone [3-5]. In ...

Over the past decade, engineering principles have been used to explain why a mechanical load, intraocular pressure, can lead to the development of glaucomatous optic neuropathy. This has led to the 'biomechanical theory' of glaucoma, which posits that the behavior of optic nerve head connective tissues (specifically within the peripapillary sclera and lamina cribrosa) in response to intraocular...

all we have to work with, at first. Yet that does not mean that behavior cannot be addressed by indirect scientific means. Here we use two intertwined case studies from our research on animal limb biomechanics, one on extinct dinosaurs and another on extant elephants, to illustrate how anatomical methods and evidence are used to solve basic questions. The dinosaur study is used to show how biom...

Quantifying cellular behavior by motility and morphology changes are increasingly important in formulating an understanding of fundamental physiological phenomena and disease mechanisms such as cancer. However, cells are complex biological units which often respond to external environmental factors by manifesting subtle responses that may be difficult to quantify using conventional biophysical ...

Understanding the biomechanical properties and the effect of biomechanical force on epithelial cells is key to understanding how epithelial cells form uniquely shaped structures in two or three-dimensional space. Nevertheless, with the limitations and challenges posed by biological experiments at this scale, it becomes advantageous to use mathematical and 'in silico' (computational) models as a...