نتایج جستجو برای: biological accessibility

تعداد نتایج: 494919  

2010
Damian Smedley Paul N. Schofield Chao-Kung Chen Vassilis Aidinis Chrysanthi Ainali Jonathan B. L. Bard Rudi Balling Ewan Birney Andrew Blake Erik Bongcam-Rudloff Anthony J. Brookes Gianni Cesareni Christina Chandras Janan T. Eppig Paul Flicek Georgios V. Gkoutos Simon Greenaway Michael Gruenberger Jean-Karim Hériché Andrew Lyall Ann-Marie Mallon Dawn Muddyman Florian Reisinger Martin Ringwald Nadia A. Rosenthal Klaus Schughart Morris A. Swertz Gudmundur A. Thorisson Michael Zouberakis John M. Hancock

The recent explosion of biological data and the concomitant proliferation of distributed databases make it challenging for biologists and bioinformaticians to discover the best data resources for their needs, and the most efficient way to access and use them. Despite a rapid acceleration in uptake of syntactic and semantic standards for interoperability, it is still difficult for users to find ...

2014
Eduard Klein Anton Bolfing Markus Riesch

The internet has become an indispensable tool for the access of information. However, most websites are not sufficiently accessible for people with disabilities. Accessibility problems originate from either the underlying CMS systems or from content authors disregarding fundamental accessibility requirements. With the Content Accessibility Checker CAC we give a tool at hand to specifically red-...

Journal: :Acta poloniae pharmaceutica 2008
Michał Zimecki Marcin Maczyński Jolanta Artym Stanisław Ryng

Advances of modern medicine require constant supply of new drugs displaying specific therapeutic actions. Bio-accessibility and lack of side-effects are highly desired features of new therapeutics. Modifications of the isoxazole structure offer a possibility of generating potential drugs exhibiting a wide array of biological activities, as described by us during the last decade (1-10). A majori...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Sabine M Görisch Malte Wachsmuth Carina Ittrich Christian P Bacher Karsten Rippe Peter Lichter

Promyelocytic leukemia (PML) and Cajal bodies are mobile subnuclear organelles, which are involved in activities like RNA processing, transcriptional regulation, and antiviral defense. A key parameter in understanding their biological functions is their mobility. The diffusion properties of PML and Cajal bodies were compared with a biochemically inactive body formed by aggregates of murine Mx1 ...

2015
Jacob D. Hinkle Peter N. Ciesielski Kenny Gruchalla Kristin R. Munch Bryon S. Donohoe

BACKGROUND Substrate accessibility to catalysts has been a dominant theme in theories of biomass deconstruction. However, current methods of quantifying accessibility do not elucidate mechanisms for increased accessibility due to changes in microstructure following pretreatment. RESULTS We introduce methods for characterization of surface accessibility based on fine-scale microstructure of th...

2008
Giorgio Brajnik

The topic I want to address is the role that accessibility evaluation methods can play in helping the transition from accessibility viewed as standard conformance, to a user-centered accessibility. As we will see, this change sets additional requirements on how evaluations of websites should be carried out. This paper first discusses different problems that occur while dealing with accessibilit...

2014
Eun-Ju Park Yang-Won Lim Han-Kyu Lim

HTML5 is the next generation of web standards, and needs to be used to improve Web accessibility. To do this, Korea has taken various activities, such as laying down laws and standards related to web accessibility and investigating the realities of web accessibility. Recently, the market for web accessibility has been growing. This study compared the rates of building up HTML5, focusing on the ...

2007
Tianyi Chen

This report is intended to be the conduit by which information is passed from the PhD student to the RA (who started 6 months after). It contains a review of the current literature on the Accessible Web and the Mobile Web. The report discusses approaches and guidelines on achieving and evaluating Web Accessibility. It also explains characteristics of the Mobile Web and discusses related accessi...

1999
Kim Lan Sim Tomoyuki Uchida Satoru Miyano

Disorder in protein structure and function have received very little attention even though the significance of these disordered regions from the functional aspects cannot be denied [2, 3, 5]. Protein Data Bank (PDB) which contains the largest collection of structural information of proteins is also the main source of disordered proteins. However, due to the lack of organised annotation and coll...

Journal: :Genes & development 2005
Chang Seob Kwon Changbin Chen Doris Wagner

SNF2 chromatin-remodeling ATPases play an important role in ensuring proper development in higher eukaryotes by controlling accessibility of cis-regulatory DNA regions to transcription factors and to the transcriptional machinery. However, the biological targets controlled by these ATPases are largely unknown. Using genetic and molecular analyses we have identified WUSCHEL (WUS) as a biological...

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