نتایج جستجو برای: biologic width
تعداد نتایج: 124793 فیلتر نتایج به سال:
This paper reviews the new biologic agents that selectively block the immunologic steps implicated in the pathogenesis of psoriasis. Four strategies have been targeted: reduction of the number of pathogenic T cells; inhibition of T-cell activation and migration; modulation of the immune system; and blockage of the activity of inflammatory cytokines. There are three classes: monoclonal antibodie...
BACKGROUND Axial spondyloarthropathy typically has its onset in early adulthood and can impact significantly on quality of life. In the UK, biologic anti-tumour necrosis factor therapy is recommended for patients who are unresponsive to non-steroidal anti-inflammatory drugs. There remain several unresolved issues about the long-term safety and quality of life outcomes of biologic treatment in a...
Although biologics are important inflammatory bowel disease therapies, loss of response (LOR) remains problematic. We evaluated LOR to biologics in our Crohn disease (CD) patients receiving biologics. Of 137 biologic-treated CD patients, 68 continuously receiving the same biologic type for at least 1 year were divided into 2 groups: infliximab (IFX) (n = 39) and adalimumab (ADA) (n = 29). Clini...
Kolmogorov argued that the concept of information exists also in problems with no underlying stochastic model (as Shannon’s information representation) for instance, the information contained in an algorithm or in the genome. He introduced a combinatorial notion of entropy and information I(x : y) conveyed by a binary string x about the unknown value of a variable y. The current paper poses the...
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