In his massive multi-volume work Technics and Time Bernard Stiegler explores a history of technics as epiphylogenesis—the preservation in technical objects of epigenetic experience. Epiphylogenesis for Stiegler marks a break with genetic evolution (which cannot preserve the lessons of experience), a break which also constitutes the “invention” of the human. As Stiegler puts it in the general in...

Pluto and its largest satellite, Charon, currently orbit in a mutually synchronous state; both bodies continuously show the same face to one another. This orbital configuration is a natural end-state for bodies that have undergone tidal dissipation. In order to achieve this state, both bodies would have experienced tidal heating and stress, with the extent of tidal activity controlled by the or...

Two-dimensional electron systems in the presence of a magnetic field support topologically ordered states, in which the coexistence of an insulating bulk with conducting one-dimensional chiral edge states gives rise to the quantum Hall effect. For systems confined by sharp boundaries, theory predicts a unique edge-bulk correspondence, which is central to proposals of quantum Hall-based topologi...

Although biologics are important inflammatory bowel disease therapies, loss of response (LOR) remains problematic. We evaluated LOR to biologics in our Crohn disease (CD) patients receiving biologics. Of 137 biologic-treated CD patients, 68 continuously receiving the same biologic type for at least 1 year were divided into 2 groups: infliximab (IFX) (n = 39) and adalimumab (ADA) (n = 29). Clini...

T H E CHRONIC myeloproliferative disorders provide a clinical setting for evaluating the evolution of relatively benign to frankly malignant neoplasia. Controversy exists regarding the categorization of patients with clonal myeloid diseases whose marrow myelodysplastic features and clinical courses are intermediate between those of the relatively clearly defined entities of acute and chronic my...

Abstract Continental depositional environments preserve the majority of the macrofloral record since the advent of land-plant colonization in the mid-Paleozoic, and wetland representatives are encountered more commonly than those that grew under more seasonal conditions. It has been assumed that preservation potential and future recovery of plant debris are high once detritus is introduced into...

We present a study of the structural evolution of protein aggregates formed in solutions of a globular protein, β-lactoglobulin (BLG), in the presence of YCl3. These aggregates are often observed before crystallization starts and they are metastable with respect to the crystalline phase. Here we focus on the characterization of the hierarchical structure of this intermediate phase and its tempe...

The impact of adaptation on the persistence of a balanced polymorphism was explored using the lactose operon of Escherichia coli as a model system. Competition in chemostats for two substitutable resources, methylgalactoside and lactulose, generates stabilizing frequency-dependent selection when two different naturally isolated lac operons (TD2 and TD10) are used. The fate of this balanced poly...

The therapeutic dilemma that confronts the management of patients with myelodysplastic syndromes (MDS) is illustrated by the absence of a Food and Drug Administration-approved agent with an indication for this disease. Clinical heterogeneity and inadequate understanding of the disease pathobiology have limited progress in the development of novel therapeutics. Preclinical investigations indicat...

Gene duplication has been widely recognized as a major driver of evolutionary change and organismal complexity through the generation of multi-gene families. Therefore, understanding the forces that govern the evolution of gene families through the retention or loss of duplicated genes is fundamentally important in our efforts to study genome evolution. Previous work from our lab has shown that...