Abstract The CCCH-type zinc finger (ZnF) containing ZC3H12 ribonucleases are crucial in post-transcriptional immune homoeostasis with ZC3H12A being the only structurally studied member of family. In this study, we present a structural-biochemical characterization ZC3H12C, which is linked chronic disorders like psoriasis. We established that RNA substrate cooperatively recognized by PIN and ZnF ...